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Adaptation and Therapeutic Exploitation of the Plasma Membrane of African Trypanosomes

School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
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Genes 2018, 9(7), 368; https://doi.org/10.3390/genes9070368
Received: 24 June 2018 / Revised: 18 July 2018 / Accepted: 19 July 2018 / Published: 20 July 2018
(This article belongs to the Special Issue Membrane Proteins in Parasitic Protozoa)
African trypanosomes are highly divergent from their metazoan hosts, and as part of adaptation to a parasitic life style have developed a unique endomembrane system. The key virulence mechanism of many pathogens is successful immune evasion, to enable survival within a host, a feature that requires both genetic events and membrane transport mechanisms in African trypanosomes. Intracellular trafficking not only plays a role in immune evasion, but also in homeostasis of intracellular and extracellular compartments and interactions with the environment. Significantly, historical and recent work has unraveled some of the connections between these processes and highlighted how immune evasion mechanisms that are associated with adaptations to membrane trafficking may have, paradoxically, provided specific sensitivity to drugs. Here, we explore these advances in understanding the membrane composition of the trypanosome plasma membrane and organelles and provide a perspective for how transport could be exploited for therapeutic purposes. View Full-Text
Keywords: Trypanosoma brucei; surface proteome; endomembrane system; endocytosis; drug development; nanobodies Trypanosoma brucei; surface proteome; endomembrane system; endocytosis; drug development; nanobodies
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MDPI and ACS Style

Quintana, J.F.; Del Pino, R.C.; Yamada, K.; Zhang, N.; Field, M.C. Adaptation and Therapeutic Exploitation of the Plasma Membrane of African Trypanosomes. Genes 2018, 9, 368. https://doi.org/10.3390/genes9070368

AMA Style

Quintana JF, Del Pino RC, Yamada K, Zhang N, Field MC. Adaptation and Therapeutic Exploitation of the Plasma Membrane of African Trypanosomes. Genes. 2018; 9(7):368. https://doi.org/10.3390/genes9070368

Chicago/Turabian Style

Quintana, Juan F., Ricardo Canavate Del Pino, Kayo Yamada, Ning Zhang, and Mark C. Field 2018. "Adaptation and Therapeutic Exploitation of the Plasma Membrane of African Trypanosomes" Genes 9, no. 7: 368. https://doi.org/10.3390/genes9070368

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