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Genes 2018, 9(2), 101; https://doi.org/10.3390/genes9020101

Modeling the Role of Wnt Signaling in Human and Drosophila Stem Cells

1
Yale-NUS College Research Labs, Singapore 117608, Singapore
2
Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore
Authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 28 December 2017 / Revised: 8 February 2018 / Accepted: 9 February 2018 / Published: 16 February 2018
(This article belongs to the Special Issue Wnt Signaling in Stem Cells)
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Abstract

The discovery of induced pluripotent stem (iPS) cells, barely more than a decade ago, dramatically transformed the study of stem cells and introduced a completely new way to approach many human health concerns. Although advances have pushed the field forward, human application remains some years away, in part due to the need for an in-depth mechanistic understanding. The role of Wnts in stem cells predates the discovery of iPS cells with Wnts established as major pluripotency promoting factors. Most work to date has been done using mouse and tissue culture models and few attempts have been made in other model organisms, but the recent combination of clustered regularly interspaced short palindromic repeats (CRISPR) gene editing with iPS cell technology provides a perfect avenue for exploring iPS cells in model organisms. Drosophila is an ideal organism for such studies, but fly iPS cells have not yet been made. In this opinion article, we draw parallels between Wnt signaling in human and Drosophila stem cell systems, propose ways to obtain Drosophila iPS cells, and suggest ways to exploit the versatility of the Drosophila system for future stem cell studies. View Full-Text
Keywords: Wnt; stem cells; Drosophila; induced pluripotent stem cells Wnt; stem cells; Drosophila; induced pluripotent stem cells
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Kaur, P.; Jin, H.J.; Lusk, J.B.; Tolwinski, N.S. Modeling the Role of Wnt Signaling in Human and Drosophila Stem Cells. Genes 2018, 9, 101.

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