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Anatomy of Mammalian Replication Domains

Department of Biochemistry and Proteomics, Graduate School of Medicine, Mie University, Tsu, Mie 514-8507, Japan
Laboratory of Molecular and Cellular Biology, Department of Life Sciences, Graduate School of Bioresources, Mie University, Tsu, Mie 514-8507, Japan
Authors to whom correspondence should be addressed.
Academic Editor: Eishi Noguchi
Genes 2017, 8(4), 110;
Received: 8 December 2016 / Revised: 22 March 2017 / Accepted: 24 March 2017 / Published: 28 March 2017
(This article belongs to the Special Issue DNA Replication Controls)
PDF [1569 KB, uploaded 28 March 2017]


Genetic information is faithfully copied by DNA replication through many rounds of cell division. In mammals, DNA is replicated in Mb-sized chromosomal units called “replication domains.” While genome-wide maps in multiple cell types and disease states have uncovered both dynamic and static properties of replication domains, we are still in the process of understanding the mechanisms that give rise to these properties. A better understanding of the molecular basis of replication domain regulation will bring new insights into chromosome structure and function. View Full-Text
Keywords: DNA replication; mammalian chromosome; replication domain; replication foci; replication origin DNA replication; mammalian chromosome; replication domain; replication foci; replication origin

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Takebayashi, S.-I.; Ogata, M.; Okumura, K. Anatomy of Mammalian Replication Domains. Genes 2017, 8, 110.

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