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Dynamics of p53: A Master Decider of Cell Fate

Department of Environmental Health and Occupational Medicine, Sichuan University West China School of Public Health, Chengdu 610041, China
College of Food Science, Sichuan Agricultural University, Yaan 625014, China
Biochemistry Ph.D. Program, Florida International University, Miami, FL 33199, USA
Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA
Biomolecular Sciences Institute, School of Integrated Sciences and Humanity, Florida International University, Miami, FL 33199, USA
Authors to whom correspondence should be addressed.
Genes 2017, 8(2), 66;
Received: 20 December 2016 / Accepted: 28 January 2017 / Published: 9 February 2017
(This article belongs to the Section Molecular Genetics and Genomics)
PDF [1467 KB, uploaded 13 February 2017]


Cellular stress‐induced temporal alterations—i.e., dynamics—are typically exemplified by the dynamics of p53 that serve as a master to determine cell fate. p53 dynamics were initially identified as the variations of p53 protein levels. However, a growing number of studies have shown that p53 dynamics are also manifested in variations in the activity, spatial location, and posttranslational modifications of p53 proteins, as well as the interplay among all p53 dynamical features. These are essential in determining a specific outcome of cell fate. In this review, we discuss the importance of the multifaceted features of p53 dynamics and their roles in the cell fate decision process, as well as their potential applications in p53‐based cancer therapy. The review provides new insights into p53 signaling pathways and their potentials in the development of new strategies in p53‐based cancer therapy. View Full-Text
Keywords: p53 dynamics; cell fate decision; cell signaling network p53 dynamics; cell fate decision; cell signaling network

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Luo, Q.; Beaver, J.M.; Liu, Y.; Zhang, Z. Dynamics of p53: A Master Decider of Cell Fate. Genes 2017, 8, 66.

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