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Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases

Molecular Morphology Laboratory, AC Camargo Cancer Center, São Paulo 01508-010, Brazil
Molecular Gynecology Laboratory, Gynecologic Department, Federal University of São Paulo, São Paulo, Brazil
Author to whom correspondence should be addressed.
Academic Editors: George A. Calin and Muller Fabbri
Received: 15 September 2016 / Revised: 20 November 2016 / Accepted: 14 December 2016 / Published: 23 December 2016
(This article belongs to the Special Issue microRNAs and Other Non-Coding RNAs in Human Diseases)
PDF [1518 KB, uploaded 23 December 2016]


Tobacco and alcohol are the leading environmental risk factors in the development of human diseases, such as cancer, cardiovascular disease, and liver injury. Despite the copious amount of research on this topic, by 2030, 8.3 million deaths are projected to occur worldwide due to tobacco use. The expression of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), is modulated by tobacco and alcohol consumption. Drinking alcohol and smoking cigarettes can modulate the expression of miRNAs and lncRNAs through various signaling pathways, such as apoptosis, angiogenesis, and inflammatory pathways—primarily interleukin 6 (IL-6)/signal transducer and activator of transcription 3 (STAT3), which seems to play a major role in the development of diseases associated with these risk factors. Since they may be predictive and prognostic biomarkers, they can be used both as predictors of the response to therapy and as a targeted therapy. Further, circulating miRNAs might be valuable noninvasive tools that can be used to examine diseases that are related to the use of tobacco and alcohol. This review discusses the function of noncoding RNAs in cancer and other human tobacco- and alcohol-associated diseases. View Full-Text
Keywords: noncoding RNAs; microRNAs; long noncoding RNAs; tobacco; alcohol; cancer; chronic obstructive pulmonary disease; cardiovascular diseases noncoding RNAs; microRNAs; long noncoding RNAs; tobacco; alcohol; cancer; chronic obstructive pulmonary disease; cardiovascular diseases

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Soares do Amaral, N.; Cruz e Melo, N.; De Melo Maia, B.; Malagoli Rocha, R. Noncoding RNA Profiles in Tobacco- and Alcohol-Associated Diseases. Genes 2017, 8, 6.

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