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Genes 2017, 8(1), 21; https://doi.org/10.3390/genes8010021

Targeting MicroRNAs in Cancer Gene Therapy

,
and
*
Department of Molecular Oncology, Eastern Hepatobiliary Surgery Hospital & National Center of Liver Cancer, Second Military Medical University, Shanghai 200433, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Michael Barry
Received: 18 November 2016 / Revised: 28 December 2016 / Accepted: 30 December 2016 / Published: 9 January 2017
(This article belongs to the Special Issue Gene Therapy)
Full-Text   |   PDF [243 KB, uploaded 9 January 2017]

Abstract

MicroRNAs (miRNAs) are a kind of conserved small non-coding RNAs that participate in regulating gene expression by targeting multiple molecules. Early studies have shown that the expression of miRNAs changes significantly in different tumor tissues and cancer cell lines. It is well acknowledged that such variation is involved in almost all biological processes, including cell proliferation, mobility, survival and differentiation. Increasing experimental data indicate that miRNA dysregulation is a biomarker of several pathological conditions including cancer, and that miRNA can exert a causal role, as oncogenes or tumor suppressor genes, in different steps of the tumorigenic process. Anticancer therapies based on miRNAs are currently being developed with a goal to improve outcomes of cancer treatment. In our present study, we review the function of miRNAs in tumorigenesis and development, and discuss the latest clinical applications and strategies of therapy targeting miRNAs in cancer. View Full-Text
Keywords: cancer; microRNA; gene therapy; oncogene; tumor suppressor gene cancer; microRNA; gene therapy; oncogene; tumor suppressor gene
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ji, W.; Sun, B.; Su, C. Targeting MicroRNAs in Cancer Gene Therapy. Genes 2017, 8, 21.

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