Telomeres and Telomerase in Cardiovascular Diseases
Abstract
:1. Introduction
2. Telomeres and Telomerase
3. Implication of Experimental Studies
3.1. Endothelial Cells
3.2. Vascular Smooth Muscle Cells
3.3. Immune Cells
3.4. Cardiomyocytes
3.5. Endothelial Progenitor Cells
4. Implications for Cardiovascular Diseases
4.1. Measurement of Telomere Length
4.2. Genetic Factors
4.3. Cardiovascular Risk Factors
4.4. Coronary Artery Diseases
4.5. Heart Failure
5. Association with Other CVDs
Therapeutic Consideration
6. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
Abbreviations
CVD | cardiovascular diseases |
CTC1 | conserved telomere maintenance complex component 1 |
CMV | cytomegalovirus |
DES | drug-eluting stent |
eNOS | endothelial nitric oxide synthase |
EPC | endothelial progenitor cells |
GWAS | genomewide association study |
HF | heart failure |
HSC | hematopoietic stem cells |
ICAM-1 | intercellular adhesion molecule 1 |
LTL | leukocyte telomere length |
MI | myocardial infarction |
PAD | peripheral artery disease |
POT1 | protection of telomere 1 |
qPCR | quantitative polymerase chain reaction |
Rap1 | repressor activator protein 1 |
ROS | reactive oxygen species |
SASP | senescence-associated secretory phenotype |
SCD | sudden cardiac death (SCD) |
SD | standard deviation |
SIPS | stress-induced premature senescence |
SNP | single-nucleotide polymorphism |
TERC | telomerase RNA component |
TERT | telomerase reverse transcriptase |
TL | telomere length |
TRF1 | telomere repeat-binding factor1 |
TIN2 | TRF1 and TRF2 interacting nuclear protein 2 |
TPP1 | tripeptidyl-peptidase 1 |
VSMC | vascular smooth muscle cells |
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Yeh, J.-K.; Wang, C.-Y. Telomeres and Telomerase in Cardiovascular Diseases. Genes 2016, 7, 58. https://doi.org/10.3390/genes7090058
Yeh J-K, Wang C-Y. Telomeres and Telomerase in Cardiovascular Diseases. Genes. 2016; 7(9):58. https://doi.org/10.3390/genes7090058
Chicago/Turabian StyleYeh, Jih-Kai, and Chao-Yung Wang. 2016. "Telomeres and Telomerase in Cardiovascular Diseases" Genes 7, no. 9: 58. https://doi.org/10.3390/genes7090058