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Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene

by 1,†, 1,†, 1,† and 1,2,*
1
Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore 169857, Singapore
2
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Gabriele Saretzki
Genes 2016, 7(8), 50; https://doi.org/10.3390/genes7080050
Received: 15 June 2016 / Revised: 23 July 2016 / Accepted: 1 August 2016 / Published: 18 August 2016
(This article belongs to the Special Issue Telomerase Activity in Human Cells)
Embryonic stem cells and induced pluripotent stem cells have the ability to maintain their telomere length via expression of an enzymatic complex called telomerase. Similarly, more than 85%–90% of cancer cells are found to upregulate the expression of telomerase, conferring them with the potential to proliferate indefinitely. Telomerase Reverse Transcriptase (TERT), the catalytic subunit of telomerase holoenzyme, is the rate-limiting factor in reconstituting telomerase activity in vivo. To date, the expression and function of the human Telomerase Reverse Transcriptase (hTERT) gene are known to be regulated at various molecular levels (including genetic, mRNA, protein and subcellular localization) by a number of diverse factors. Among these means of regulation, transcription modulation is the most important, as evident in its tight regulation in cancer cell survival as well as pluripotent stem cell maintenance and differentiation. Here, we discuss how hTERT gene transcription is regulated, mainly focusing on the contribution of trans-acting factors such as transcription factors and epigenetic modifiers, as well as genetic alterations in hTERT proximal promoter. View Full-Text
Keywords: telomerase; telomere; transcription regulation; promoter; mutation telomerase; telomere; transcription regulation; promoter; mutation
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MDPI and ACS Style

Ramlee, M.K.; Wang, J.; Toh, W.X.; Li, S. Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene. Genes 2016, 7, 50. https://doi.org/10.3390/genes7080050

AMA Style

Ramlee MK, Wang J, Toh WX, Li S. Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene. Genes. 2016; 7(8):50. https://doi.org/10.3390/genes7080050

Chicago/Turabian Style

Ramlee, Muhammad K., Jing Wang, Wei X. Toh, and Shang Li. 2016. "Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene" Genes 7, no. 8: 50. https://doi.org/10.3390/genes7080050

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