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Genes 2016, 7(12), 126;

Regulation of Pseudomonas aeruginosa Virulence by Distinct Iron Sources

Wound Infections Department, Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
Department of Pharmaceutical Sciences, School of Pharmacy, and Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
Author to whom correspondence should be addressed.
Academic Editor: Helen J. Wing
Received: 7 October 2016 / Revised: 2 December 2016 / Accepted: 5 December 2016 / Published: 14 December 2016
(This article belongs to the Special Issue Virulence Gene Regulation in Bacteria)
Full-Text   |   PDF [757 KB, uploaded 14 December 2016]   |  


Pseudomonas aeruginosa is a ubiquitous environmental bacterium and versatile opportunistic pathogen. Like most other organisms, P. aeruginosa requires iron for survival, yet iron rapidly reacts with oxygen and water to form stable ferric (FeIII) oxides and hydroxides, limiting its availability to living organisms. During infection, iron is also sequestered by the host innate immune system, further limiting its availability. P. aeruginosa’s capacity to cause disease in diverse host environments is due to its ability to scavenge iron from a variety of host iron sources. Work over the past two decades has further shown that different iron sources can affect the expression of distinct virulence traits. This review discusses how the individual components of P. aeruginosa’s iron regulatory network allow this opportunist to adapt to a multitude of host environments during infection. View Full-Text
Keywords: Pseudomonas aeruginosa; heme; siderophores; iron; small RNAs; biofilms Pseudomonas aeruginosa; heme; siderophores; iron; small RNAs; biofilms

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Reinhart, A.A.; Oglesby-Sherrouse, A.G. Regulation of Pseudomonas aeruginosa Virulence by Distinct Iron Sources. Genes 2016, 7, 126.

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