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RNA Export through the NPC in Eukaryotes
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Nuclear Export of Messenger RNA

Biomolecular Networks Laboratories, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan
Department of Biochemistry, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan 
Academic Editor: Rozanne M. Sandri-Goldin
Genes 2015, 6(2), 163-184;
Received: 30 January 2015 / Revised: 23 March 2015 / Accepted: 24 March 2015 / Published: 31 March 2015
(This article belongs to the Special Issue Mechanisms of mRNA Nuclear Export)
Transport of messenger RNA (mRNA) from the nucleus to the cytoplasm is an essential step of eukaryotic gene expression. In the cell nucleus, a precursor mRNA undergoes a series of processing steps, including capping at the 5' ends, splicing and cleavage/polyadenylation at the 3' ends. During this process, the mRNA associates with a wide variety of proteins, forming a messenger ribonucleoprotein (mRNP) particle. Association with factors involved in nuclear export also occurs during transcription and processing, and thus nuclear export is fully integrated into mRNA maturation. The coupling between mRNA maturation and nuclear export is an important mechanism for providing only fully functional and competent mRNA to the cytoplasmic translational machinery, thereby ensuring accuracy and swiftness of gene expression. This review describes the molecular mechanism of nuclear mRNA export mediated by the principal transport factors, including Tap-p15 and the TREX complex. View Full-Text
Keywords: nucleo-cytoplasmic transport; Nxf1-Nxt1; mRNA; TREX complex nucleo-cytoplasmic transport; Nxf1-Nxt1; mRNA; TREX complex
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Katahira, J. Nuclear Export of Messenger RNA. Genes 2015, 6, 163-184.

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