RNF213-Related Vasculopathy: An Entity with Diverse Phenotypic Expressions
Abstract
1. Introduction
2. Systemic Associations of RRV
2.1. Intracranial Arterial Stenosis/Occlusion
2.2. Systemic Hypertension
2.3. Early-Onset Coronary Artery Disease and Myocardial Infarction
2.4. Coronary Vasospasm: Vasospastic Angina
2.5. Pulmonary Arterial Hypertension
2.6. Sporadic Aortic Dissection
2.7. Carotid Artery
2.8. Stenosis of Abdominal Branches of the Aorta
2.9. Neurocristopathy and Rare Syndromes
- Brain: Moyamoya disease, intracranial arterial stenosis, and ischemic stroke
- Carotid artery: Large-artery atherosclerosis or non-atherosclerotic narrowing
- Heart: Coronary artery disease and vasospastic angina
- Pulmonary arteries: Chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension
- Aorta: Aortic dissection
- Abdominal aortic branches: Renal artery stenosis
3. Molecular Mechanisms
3.1. RNF213 Structure and Enzymatic Functions
3.2. Impact of the p.R4810K Mutation
3.3. Endothelial Function and Inflammation
3.4. Caveolin-1
3.5. Lipid Metabolism
3.6. Angiogenic Dysregulation
3.7. Stress-Dependent Vascular Vulnerability
3.8. Endothelial Specificity
3.9. Functional Impairments in iPSC-Derived Vascular Cells Harboring RNF213 Mutations
3.10. Pathological Significance of Rare RNF213 Variants Including Truncating Mutations
3.11. Summary
4. Cerebrovascular Manifestations
4.1. Arterial Remodeling
4.2. Risk Factor Profile
4.3. Natural History and Outcomes
4.4. Genotype–Phenotype Correlation of RNF213 p.R4810K Variant in Cerebrovascular Disease
4.5. Advanced Neuroimaging Features in RNF213 Variant Carriers
5. Therapeutic Perspectives
5.1. Modifying Second-Hit Triggers
5.2. Promoting Angiogenesis and Collateral Formation
5.3. Medications
5.4. Intervention
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Therapeutic Class | Candidate(s) | Proposed Mechanism | Supporting Evidence | Current Status/Challenges |
---|---|---|---|---|
Statins | Atorvastatin Rosuvastatin | ↑ eNOS activity ↓ Oxidative stress ↑ NO bioavailability | HR 0.20 for stenosis progression in RNF213 carriers | Observational data only; trials needed |
Angiogenic Agents | VEGF, HGF, FGF2 | Promotion of collateral vessel development | Preclinical models; case reports in MMD suggest potential benefit | Primarily preclinical; limited trials |
Immunomodulatory Drugs | Rituximab Corticosteroids | Suppression of vascular inflammation | High prevalence of autoimmune thyroiditis in RNF213 carriers suggests a potential pathogenic role | Hypothesis-driven; untested clinically |
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Yoshimoto, T.; Okune, S.; Tanaka, S.; Yamagami, H.; Matsumaru, Y. RNF213-Related Vasculopathy: An Entity with Diverse Phenotypic Expressions. Genes 2025, 16, 939. https://doi.org/10.3390/genes16080939
Yoshimoto T, Okune S, Tanaka S, Yamagami H, Matsumaru Y. RNF213-Related Vasculopathy: An Entity with Diverse Phenotypic Expressions. Genes. 2025; 16(8):939. https://doi.org/10.3390/genes16080939
Chicago/Turabian StyleYoshimoto, Takeshi, Sho Okune, Shun Tanaka, Hiroshi Yamagami, and Yuji Matsumaru. 2025. "RNF213-Related Vasculopathy: An Entity with Diverse Phenotypic Expressions" Genes 16, no. 8: 939. https://doi.org/10.3390/genes16080939
APA StyleYoshimoto, T., Okune, S., Tanaka, S., Yamagami, H., & Matsumaru, Y. (2025). RNF213-Related Vasculopathy: An Entity with Diverse Phenotypic Expressions. Genes, 16(8), 939. https://doi.org/10.3390/genes16080939