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Volume 13
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10.3390/genes13071213
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Article

DNA Methylation-Specific Analysis of G Protein-Coupled Receptor-Related Genes in Pan-Cancer

by
Mengyan Zhang
1,†,
Jiyun Zhao
1,†,
Huili Dong
1,
Wenhui Xue
1,
Jie Xing
1,
Ting Liu
2,
Xiuwen Yu
2,
Yue Gu
1,
Baoqing Sun
3,
Haibo Lu
4,* and
Yan Zhang
1,2,3,*
1
Computational Biology Research Center, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China
2
College of pathology, Qiqihar Medical University, Qiqihar 161042, China
3
State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou 510089, China
4
Department of Gastrointestinal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin 150000, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Genes 2022, 13(7), 1213; https://doi.org/10.3390/genes13071213
Submission received: 2 June 2022 / Revised: 24 June 2022 / Accepted: 5 July 2022 / Published: 7 July 2022
(This article belongs to the Special Issue DNA and RNA Epigenetics and Transcriptomics Research)
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Abstract

Tumor heterogeneity presents challenges for personalized diagnosis and treatment of cancer. The identification method of cancer-specific biomarkers has important applications for the diagnosis and treatment of cancer types. In this study, we analyzed the pan-cancer DNA methylation data from TCGA and GEO, and proposed a computational method to quantify the degree of specificity based on the level of DNA methylation of G protein-coupled receptor-related genes (GPCRs-related genes) and to identify specific GPCRs DNA methylation biomarkers (GRSDMs) in pan-cancer. Then, a ridge regression-based method was used to discover potential drugs through predicting the drug sensitivities of cancer samples. Finally, we predicted and verified 8 GRSDMs in adrenocortical carcinoma (ACC), rectum adenocarcinoma (READ), uveal Melanoma (UVM), thyroid carcinoma (THCA), and predicted 4 GRSDMs (F2RL3, DGKB, GRK5, PIK3R6) which were sensitive to 12 potential drugs. Our research provided a novel approach for the personalized diagnosis of cancer and informed individualized treatment decisions.
Keywords: G protein-coupled receptor; DNA methylation; biomarker; drug sensitivity G protein-coupled receptor; DNA methylation; biomarker; drug sensitivity
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MDPI and ACS Style

Zhang, M.; Zhao, J.; Dong, H.; Xue, W.; Xing, J.; Liu, T.; Yu, X.; Gu, Y.; Sun, B.; Lu, H.; et al. DNA Methylation-Specific Analysis of G Protein-Coupled Receptor-Related Genes in Pan-Cancer. Genes 2022, 13, 1213. https://doi.org/10.3390/genes13071213

AMA Style

Zhang M, Zhao J, Dong H, Xue W, Xing J, Liu T, Yu X, Gu Y, Sun B, Lu H, et al. DNA Methylation-Specific Analysis of G Protein-Coupled Receptor-Related Genes in Pan-Cancer. Genes. 2022; 13(7):1213. https://doi.org/10.3390/genes13071213

Chicago/Turabian Style

Zhang, Mengyan, Jiyun Zhao, Huili Dong, Wenhui Xue, Jie Xing, Ting Liu, Xiuwen Yu, Yue Gu, Baoqing Sun, Haibo Lu, and et al. 2022. "DNA Methylation-Specific Analysis of G Protein-Coupled Receptor-Related Genes in Pan-Cancer" Genes 13, no. 7: 1213. https://doi.org/10.3390/genes13071213

APA Style

Zhang, M., Zhao, J., Dong, H., Xue, W., Xing, J., Liu, T., Yu, X., Gu, Y., Sun, B., Lu, H., & Zhang, Y. (2022). DNA Methylation-Specific Analysis of G Protein-Coupled Receptor-Related Genes in Pan-Cancer. Genes, 13(7), 1213. https://doi.org/10.3390/genes13071213

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