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SIRT7 Acts as a Guardian of Cellular Integrity by Controlling Nucleolar and Extra-Nucleolar Functions

Department of Cardiac Development and Remodeling, Max-Planck-Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany
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Academic Editor: Maciej Wnuk
Genes 2021, 12(9), 1361; https://doi.org/10.3390/genes12091361
Received: 11 August 2021 / Revised: 25 August 2021 / Accepted: 29 August 2021 / Published: 30 August 2021
(This article belongs to the Special Issue Sirtuins in Stress Response, Genome Integrity and Cell Physiology)
Sirtuins are key players for maintaining cellular homeostasis and are often deregulated in different human diseases. SIRT7 is the only member of mammalian sirtuins that principally resides in the nucleolus, a nuclear compartment involved in ribosomal biogenesis, senescence, and cellular stress responses. The ablation of SIRT7 induces global genomic instability, premature ageing, metabolic dysfunctions, and reduced stress tolerance, highlighting its critical role in counteracting ageing-associated processes. In this review, we describe the molecular mechanisms employed by SIRT7 to ensure cellular and organismal integrity with particular emphasis on SIRT7-dependent regulation of nucleolar functions. View Full-Text
Keywords: sirtuins; SIRT7; deacetylation; stress responses; nucleolus sirtuins; SIRT7; deacetylation; stress responses; nucleolus
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MDPI and ACS Style

Kumari, P.; Tarighi, S.; Braun, T.; Ianni, A. SIRT7 Acts as a Guardian of Cellular Integrity by Controlling Nucleolar and Extra-Nucleolar Functions. Genes 2021, 12, 1361. https://doi.org/10.3390/genes12091361

AMA Style

Kumari P, Tarighi S, Braun T, Ianni A. SIRT7 Acts as a Guardian of Cellular Integrity by Controlling Nucleolar and Extra-Nucleolar Functions. Genes. 2021; 12(9):1361. https://doi.org/10.3390/genes12091361

Chicago/Turabian Style

Kumari, Poonam, Shahriar Tarighi, Thomas Braun, and Alessandro Ianni. 2021. "SIRT7 Acts as a Guardian of Cellular Integrity by Controlling Nucleolar and Extra-Nucleolar Functions" Genes 12, no. 9: 1361. https://doi.org/10.3390/genes12091361

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