Next Article in Journal
The Genomic Organisation of the TRA/TRD Locus Validates the Peculiar Characteristics of Dromedary δ-Chain Expression
Next Article in Special Issue
Molecular Characterization of Muellerian Tumors of the Urinary Tract
Previous Article in Journal
ATP-Dependent Ligases and AEP Primases Affect the Profile and Frequency of Mutations in Mycobacteria under Oxidative Stress
Previous Article in Special Issue
Downregulation of Cell Cycle and Checkpoint Genes by Class I HDAC Inhibitors Limits Synergism with G2/M Checkpoint Inhibitor MK-1775 in Bladder Cancer Cells
Article

Neuropilin-2 and Its Transcript Variants Correlate with Clinical Outcome in Bladder Cancer

1
Rudolf Becker Laboratory for Prostate Cancer Research, Institute of Pathology, University of Bonn Medical Center, 53127 Bonn, Germany
2
Department of Urology and Urosurgery, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany
3
Department of Biochemistry, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA
4
Institute of Pathology, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany
5
Bridge (Bladder Cancer Research Initiative for Drug Targets Germany) Consortium e.V., 68135 Mannheim, Germany
*
Authors to whom correspondence should be addressed.
Academic Editors: Irmgard Irminger-Finger, Nadine Gaisa and Ruth Knüchel-Clarke
Genes 2021, 12(4), 550; https://doi.org/10.3390/genes12040550
Received: 15 February 2021 / Revised: 26 March 2021 / Accepted: 7 April 2021 / Published: 9 April 2021
(This article belongs to the Special Issue Genetics and Genomics of Bladder Cancer)
Urothelial bladder cancer ranks among the 10 most frequently diagnosed cancers worldwide. In our previous study, the transmembrane protein neuropilin-2 (NRP2) emerged as a predictive marker in patients with bladder cancer. NRP2 consists of several splice variants; the most abundant of these, NRP2a and NRP2b, are reported to have different biological functions in lung cancer progression. For other cancer types, there are no published data on the role of these transcript variants in cancer progression and the clinical outcome. Here, we correlate NRP2 and its two most abundant transcript variants, NRP2A and NRP2B, with the clinical outcome using available genomic data with subsequent validation in our own cohort of patients with muscle-invasive bladder cancer. In addition to NRP2, NRP1 and the NRP ligands PDGFC and PDGFD were studied. Only NRP2A emerged as an independent prognostic marker for shorter cancer-specific survival in muscle-invasive bladder cancer in our cohort of 102 patients who underwent radical cystectomy between 2008 and 2014 with a median follow-up time of 82 months. Additionally, we demonstrate that high messenger expression of NRP2, NRP1, PDGFC and PDGFD associates with a more aggressive disease (i.e., a high T stage, positive lymph node status and reduced survival). View Full-Text
Keywords: neuropilin-2 (NRP2); neuropilin-2 transcript variants; NRP2a; bladder cancer; muscle-invasive bladder cancer (MIBC); platelet-derived growth factor (PDGF) neuropilin-2 (NRP2); neuropilin-2 transcript variants; NRP2a; bladder cancer; muscle-invasive bladder cancer (MIBC); platelet-derived growth factor (PDGF)
Show Figures

Figure 1

MDPI and ACS Style

Förster, S.; Givehchi, M.; Nitschke, K.; Mayr, T.; Kilian, K.; Dutta, S.; Datta, K.; Nuhn, P.; Popovic, Z.; Muders, M.H.; Erben, P. Neuropilin-2 and Its Transcript Variants Correlate with Clinical Outcome in Bladder Cancer. Genes 2021, 12, 550. https://doi.org/10.3390/genes12040550

AMA Style

Förster S, Givehchi M, Nitschke K, Mayr T, Kilian K, Dutta S, Datta K, Nuhn P, Popovic Z, Muders MH, Erben P. Neuropilin-2 and Its Transcript Variants Correlate with Clinical Outcome in Bladder Cancer. Genes. 2021; 12(4):550. https://doi.org/10.3390/genes12040550

Chicago/Turabian Style

Förster, Sarah, Maryam Givehchi, Katja Nitschke, Thomas Mayr, Kerstin Kilian, Samikshan Dutta, Kaustubh Datta, Philipp Nuhn, Zoran Popovic, Michael H. Muders, and Philipp Erben. 2021. "Neuropilin-2 and Its Transcript Variants Correlate with Clinical Outcome in Bladder Cancer" Genes 12, no. 4: 550. https://doi.org/10.3390/genes12040550

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop