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Review

Understanding the Adaptive Evolutionary Histories of South American Ancient and Present-Day Populations via Genomics

by 1,* and 2,*
1
Department of Anthropology, Emory University, Atlanta, GA 30322, USA
2
Department of Computer and Electrical Engineering and Computer Science, Florida Atlantic University, Boca Raton, FL 33431, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Ornella Semino
Genes 2021, 12(3), 360; https://doi.org/10.3390/genes12030360
Received: 28 January 2021 / Revised: 18 February 2021 / Accepted: 22 February 2021 / Published: 2 March 2021
(This article belongs to the Special Issue The Peopling of the Americas: A Genetic Perspective)
The South American continent is remarkably diverse in its ecological zones, spanning the Amazon rainforest, the high-altitude Andes, and Tierra del Fuego. Yet the original human populations of the continent successfully inhabited all these zones, well before the buffering effects of modern technology. Therefore, it is likely that the various cultures were successful, in part, due to positive natural selection that allowed them to successfully establish populations for thousands of years. Detecting positive selection in these populations is still in its infancy, as the ongoing effects of European contact have decimated many of these populations and introduced gene flow from outside of the continent. In this review, we explore hypotheses of possible human biological adaptation, methods to identify positive selection, the utilization of ancient DNA, and the integration of modern genomes through the identification of genomic tracts that reflect the ancestry of the first populations of the Americas. View Full-Text
Keywords: ancient DNA; natural selection; South America ancient DNA; natural selection; South America
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MDPI and ACS Style

Lindo, J.; DeGiorgio, M. Understanding the Adaptive Evolutionary Histories of South American Ancient and Present-Day Populations via Genomics. Genes 2021, 12, 360. https://doi.org/10.3390/genes12030360

AMA Style

Lindo J, DeGiorgio M. Understanding the Adaptive Evolutionary Histories of South American Ancient and Present-Day Populations via Genomics. Genes. 2021; 12(3):360. https://doi.org/10.3390/genes12030360

Chicago/Turabian Style

Lindo, John; DeGiorgio, Michael. 2021. "Understanding the Adaptive Evolutionary Histories of South American Ancient and Present-Day Populations via Genomics" Genes 12, no. 3: 360. https://doi.org/10.3390/genes12030360

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