High Olfactory Receptor-Rich 11q11 Copy Number in Girls and African American Children
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Participants
2.2. Anthropometric Measurement of the Participants
2.3. 11q11 Copy Number Measurement by 3D Digital PCR
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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11q11 Low Copy Number Variant (LCNV, n = 52) | 11q11 High Copy Number Variant (HCNV, n = 75) | F (1, 127) | p-Value | ||
---|---|---|---|---|---|
Age (year) | All Participant | 8.22 ± 0.19 | 8.53 ± 0.16 | 1.558 | p = 0.214 |
Race (n) | EA (68) | 8.26 ± 0.24 | 8.39 ± 0.24 | 0.113 | p = 0.738 |
AA (59) | 8.16 ± 0.32 | 8.66 ± 0.22 | |||
F (1, 127) = 0.541; p = 0.464 | |||||
Gender (n) | Boys (69) | 8.14 ± 0.24 | 8.45 ± 0.23 | 0.508 | p = 0.477 |
Girls (58) | 8.36 ± 0.32 | 8.60 ± 0.22 | |||
F (1, 127) = 0.016; p = 0.898 | |||||
BMI category (n) | NW (76) | 8.10 ± 0.24 | 8.55 ± 0.21 | 0.372 | p = 0.543 |
OW/OB (51) | 8.45 ± 0.33 | 8.51 ± 0.24 | |||
F (1, 127) = 0.566; p = 0.453 | |||||
Height (cm) | All Participant | 130.27 ± 1.56 | 132.81 ± 1.30 | 1.564 | p = 0.213 |
Race | EA | 129.40 ± 1.95 | 130.22 ± 1.89 | 3.057 | p = 0.083 |
AA | 131.77 ± 2.57 | 135.08 ± 1.77 | |||
F (1, 127) = 0.365; p = 0.547 | |||||
Gender | Boys | 129.02 ± 1.96 | 131.49 ± 1.88 | 2.043 | p = 0.155 |
Girls | 132.43 ± 2.59 | 134.03 ± 1.81 | |||
F (1, 127) = 0.043; p = 0.836 | |||||
BMI category | NW | 127.78 ± 1.88 | 130.46 ± 1.69 | 9.369 | p = 0.003 |
OW/OB | 134.95 ± 2.58 | 135.79 ± 1.91 | |||
F (1, 127) = 0.203; p = 0.653 | |||||
Weight (kg) | All Participant | 32.15 ± 1.53 | 32.29 ± 1.27 | 0.004 | p = 0.947 |
Race | EA | 29.79 ± 1.89 | 30.46 ± 1.83 | 6.118 | p = 0.015 |
AA | 35.26 ± 2.48 | 33.88 ± 1.71 | |||
F (1, 127) = 0.578; p = 0.448 | |||||
Gender | Boys | 32.72 ± 1.93 | 31.86 ± 1.85 | 0.033 | p = 0.856 |
Girls | 31.16 ± 2.54 | 32.68 ± 1.78 | |||
F (1, 127) = 0.340; p = 0.561 | |||||
BMI category | NW | 31.33 ± 1.90 | 32.45 ± 1.71 | 0.233 | p = 0.630 |
OW/OB | 33.71 ± 2.61 | 32.07 ± 1.93 | |||
F (1, 127) = 0.447; p = 0.505 | |||||
BMI (kg/m2) | All Participant | 17.89 ± 0.50 | 18.28 ± 0.41 | 0.363 | p = 0.548 |
Race | EA | 17.50 ± 0.62 | 17.72 ± 0.60 | 2.667 | p = 0.105 |
AA | 18.58 ± 0.82 | 18.78 ± 0.56 | |||
F (1, 127) = 0.0004; p = 0.984 | |||||
Gender | Boys | 17.25 ± 0.62 | 18.27 ± 0.59 | 1.870 | p = 0.174 |
Girls | 19.02 ± 0.82 | 18.29 ± 0.57 | |||
F (1, 127) = 1.787; p = 0.184 | |||||
BMI category | NW | 15.74 ± 0.40 | 16.10 ± 0.36 | 161.89 | p < 0.001 |
OW/OB | 21.97 ± 0.56 | 21.06 ± 0.41 | |||
F (1, 127) = 2.098; p = 0.150 | |||||
11q11 CNV | All Participant | 0.928 ± 0.04 | 2.05 ± 0.04 | 407.86 | p < 0.001 |
Race | EA | 0.917 ± 0.05 | 2.00 ± 0.05 | 0.928 | p = 0.337 |
AA | 0.948 ± 0.07 | 2.08 ± 0.05 | |||
F (1, 127) = 0.163; p = 0.687 | |||||
Gender | Boys | 0.916 ± 0.05 | 1.98 ± 0.05 | 1.777 | p = 0.185 |
Girls | 0.950 ± 0.07 | 2.10 ± 0.05 | |||
F (1, 127) = 0.527; p = 0.469 | |||||
BMI category | NW | 0.918 ± 0.05 | 2.09 ± 0.05 | 0.284 | p = 0.595 |
OW/OB | 0.948 ± 0.07 | 1.99 ± 0.05 | |||
F (1, 127) = 1.113; p = 0.294 |
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Phillips, M.; Selvaraju, V.; Fouty, A.; Babu, J.R.; Sandey, M.; Geetha, T. High Olfactory Receptor-Rich 11q11 Copy Number in Girls and African American Children. Genes 2021, 12, 1943. https://doi.org/10.3390/genes12121943
Phillips M, Selvaraju V, Fouty A, Babu JR, Sandey M, Geetha T. High Olfactory Receptor-Rich 11q11 Copy Number in Girls and African American Children. Genes. 2021; 12(12):1943. https://doi.org/10.3390/genes12121943
Chicago/Turabian StylePhillips, Megan, Vaithinathan Selvaraju, Anna Fouty, Jeganathan Ramesh Babu, Maninder Sandey, and Thangiah Geetha. 2021. "High Olfactory Receptor-Rich 11q11 Copy Number in Girls and African American Children" Genes 12, no. 12: 1943. https://doi.org/10.3390/genes12121943