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Article

Genome-Wide Selective Signatures Reveal Candidate Genes Associated with Hair Follicle Development and Wool Shedding in Sheep

1
Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China
2
College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China
*
Author to whom correspondence should be addressed.
Zhihui Lei and Weibo Sun both authors contributed equally to this work.
Academic Editor: Brenda Mae Murdoch
Genes 2021, 12(12), 1924; https://doi.org/10.3390/genes12121924
Received: 13 October 2021 / Revised: 25 November 2021 / Accepted: 27 November 2021 / Published: 29 November 2021
(This article belongs to the Section Animal Genetics and Genomics)
Hair follicle development and wool shedding in sheep are poorly understood. This study investigated the population structures and genetic differences between sheep with different wool types to identify candidate genes related to these traits. We used Illumina ovine SNP 50K chip genotyping data of 795 sheep populations comprising 27 breeds with two wool types, measuring the population differentiation index (Fst), nucleotide diversity (θπ ratio), and extended haplotype homozygosity among populations (XP-EHH) to detect the selective signatures of hair sheep and fine-wool sheep. The top 5% of the Fst and θπ ratio values, and values of XP-EHH < −2 were considered strongly selected SNP sites. Annotation showed that the PRX, SOX18, TGM3, and TCF3 genes related to hair follicle development and wool shedding were strongly selected. Our results indicated that these methods identified important genes related to hair follicle formation, epidermal differentiation, and hair follicle stem cell development, and provide a meaningful reference for further study on the molecular mechanisms of economically important traits in sheep. View Full-Text
Keywords: sheep; SNP chip; selective signatures; Fst; θπ ratio; XP-EHH sheep; SNP chip; selective signatures; Fst; θπ ratio; XP-EHH
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MDPI and ACS Style

Lei, Z.; Sun, W.; Guo, T.; Li, J.; Zhu, S.; Lu, Z.; Qiao, G.; Han, M.; Zhao, H.; Yang, B.; Zhang, L.; Liu, J.; Yuan, C.; Yue, Y. Genome-Wide Selective Signatures Reveal Candidate Genes Associated with Hair Follicle Development and Wool Shedding in Sheep. Genes 2021, 12, 1924. https://doi.org/10.3390/genes12121924

AMA Style

Lei Z, Sun W, Guo T, Li J, Zhu S, Lu Z, Qiao G, Han M, Zhao H, Yang B, Zhang L, Liu J, Yuan C, Yue Y. Genome-Wide Selective Signatures Reveal Candidate Genes Associated with Hair Follicle Development and Wool Shedding in Sheep. Genes. 2021; 12(12):1924. https://doi.org/10.3390/genes12121924

Chicago/Turabian Style

Lei, Zhihui, Weibo Sun, Tingting Guo, Jianye Li, Shaohua Zhu, Zengkui Lu, Guoyan Qiao, Mei Han, Hongchang Zhao, Bohui Yang, Liping Zhang, Jianbin Liu, Chao Yuan, and Yaojing Yue. 2021. "Genome-Wide Selective Signatures Reveal Candidate Genes Associated with Hair Follicle Development and Wool Shedding in Sheep" Genes 12, no. 12: 1924. https://doi.org/10.3390/genes12121924

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