Bioinformatic Analysis Identified Hub Genes Associated with Heterocyclic Amines Induced Cytotoxicity of Peripheral Blood Mononuclear Cells
Abstract
:1. Introduction
2. Materials and Methods
2.1. GEO Data Accession
2.2. WGCNA Analysis
2.3. LIMMA Analysis
2.4. Functional Analysis
2.5. Network Construction and Hub Gene Identification
2.6. Statistical Analysis and Plotting
3. Results
3.1. Weighted Gene Coexpression Network Analysis
3.2. Functional Analysis of the Correlated Gene Moudules
3.3. The Identification of Differentially Expressed Genes
3.4. Hub Gene Identification
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Li, X.; Dong, L.; Yu, H.; Zhang, Y.; Wang, S. Bioinformatic Analysis Identified Hub Genes Associated with Heterocyclic Amines Induced Cytotoxicity of Peripheral Blood Mononuclear Cells. Genes 2021, 12, 1888. https://doi.org/10.3390/genes12121888
Li X, Dong L, Yu H, Zhang Y, Wang S. Bioinformatic Analysis Identified Hub Genes Associated with Heterocyclic Amines Induced Cytotoxicity of Peripheral Blood Mononuclear Cells. Genes. 2021; 12(12):1888. https://doi.org/10.3390/genes12121888
Chicago/Turabian StyleLi, Xinyang, Lu Dong, Huaning Yu, Yan Zhang, and Shuo Wang. 2021. "Bioinformatic Analysis Identified Hub Genes Associated with Heterocyclic Amines Induced Cytotoxicity of Peripheral Blood Mononuclear Cells" Genes 12, no. 12: 1888. https://doi.org/10.3390/genes12121888