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Review

DNA Damage Responses during the Cell Cycle: Insights from Model Organisms and Beyond

by 1 and 1,2,*
1
Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA
2
Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Jan LaRocque and Mitch McVey
Genes 2021, 12(12), 1882; https://doi.org/10.3390/genes12121882
Received: 9 November 2021 / Revised: 22 November 2021 / Accepted: 23 November 2021 / Published: 25 November 2021
(This article belongs to the Special Issue DNA Damage Response Mechanisms in Model Systems)
Genome damage is a threat to all organisms. To respond to such damage, DNA damage responses (DDRs) lead to cell cycle arrest, DNA repair, and cell death. Many DDR components are highly conserved, whereas others have adapted to specific organismal needs. Immense progress in this field has been driven by model genetic organism research. This review has two main purposes. First, we provide a survey of model organism-based efforts to study DDRs. Second, we highlight how model organism study has contributed to understanding how specific DDRs are influenced by cell cycle stage. We also look forward, with a discussion of how future study can be expanded beyond typical model genetic organisms to further illuminate how the genome is protected. View Full-Text
Keywords: DNA damage; model organisms; cell cycle; DNA repair DNA damage; model organisms; cell cycle; DNA repair
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MDPI and ACS Style

Clay, D.E.; Fox, D.T. DNA Damage Responses during the Cell Cycle: Insights from Model Organisms and Beyond. Genes 2021, 12, 1882. https://doi.org/10.3390/genes12121882

AMA Style

Clay DE, Fox DT. DNA Damage Responses during the Cell Cycle: Insights from Model Organisms and Beyond. Genes. 2021; 12(12):1882. https://doi.org/10.3390/genes12121882

Chicago/Turabian Style

Clay, Delisa E., and Donald T. Fox. 2021. "DNA Damage Responses during the Cell Cycle: Insights from Model Organisms and Beyond" Genes 12, no. 12: 1882. https://doi.org/10.3390/genes12121882

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