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Article

MUC14-Related ncRNA-mRNA Network in Breast Cancer

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Department of Breast Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
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Department of Neurosurgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
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Department of Oncology, The First Affiliated Hospital of Jiaxing University, Jiaxing 314000, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Deborah J. Good
Genes 2021, 12(11), 1677; https://doi.org/10.3390/genes12111677
Received: 14 September 2021 / Revised: 11 October 2021 / Accepted: 21 October 2021 / Published: 23 October 2021
(This article belongs to the Special Issue Non-coding RNAs in Human Health and Diseases)
Abstract: Background Growing evidences have showed that mucins (MUCs) are linked to occurrence and progression of human cancers. However, a comprehensive study regarding the expression, diagnosis, prognosis and mechanism of MUCs in breast cancer remains absent. Methods: A series of in silico analyses were employed in this study. Results: After performing comprehensive analysis for MUCs, MUC14 was identified as the most potential regulator in breast cancer, with downregulated expression in both mRNA and protein levels and significant diagnostic and prognostic values in breast cancer. Mechanistic exploration revealed that a potential ncRNA-mRNA axis, involving LINC01128/LINC01140/SGMS1-AS1/LINC00667-miR-137/miR-429-BCL2, might be partially responsible for MUC14′s functions in breast cancer. Conclusions: Collectively, our study elucidated a key role of MUC14 in breast cancer and also provided some clues for explanation of the molecular action mechanism of MUC14 in breast cancer. View Full-Text
Keywords: mucin 14 (MUC14); noncoding RNA (ncRNA); microRNA (miRNA); breast cancer; bioinformatic analysis mucin 14 (MUC14); noncoding RNA (ncRNA); microRNA (miRNA); breast cancer; bioinformatic analysis
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MDPI and ACS Style

Wang, S.; Jin, J.; Chen, J.; Lou, W. MUC14-Related ncRNA-mRNA Network in Breast Cancer. Genes 2021, 12, 1677. https://doi.org/10.3390/genes12111677

AMA Style

Wang S, Jin J, Chen J, Lou W. MUC14-Related ncRNA-mRNA Network in Breast Cancer. Genes. 2021; 12(11):1677. https://doi.org/10.3390/genes12111677

Chicago/Turabian Style

Wang, Shuqian, Jing Jin, Jing Chen, and Weiyang Lou. 2021. "MUC14-Related ncRNA-mRNA Network in Breast Cancer" Genes 12, no. 11: 1677. https://doi.org/10.3390/genes12111677

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