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Epigenetic Regulatory Dynamics in Models of Methamphetamine-Use Disorder

Molecular Neuropsychiatry Research Branch, NIDA Intramural Research Program, Baltimore, MD 21224, USA
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Equal author contribution.
Academic Editor: Italia Di Liegro
Genes 2021, 12(10), 1614; https://doi.org/10.3390/genes12101614
Received: 6 August 2021 / Revised: 8 October 2021 / Accepted: 10 October 2021 / Published: 14 October 2021
(This article belongs to the Special Issue Gene Expression and Chromatin Modification in the Brain)
Methamphetamine (METH)-use disorder (MUD) is a very serious, potentially lethal, biopsychosocial disease. Exposure to METH causes long-term changes to brain regions involved in reward processing and motivation, leading vulnerable individuals to engage in pathological drug-seeking and drug-taking behavior that can remain a lifelong struggle. It is crucial to elucidate underlying mechanisms by which exposure to METH leads to molecular neuroadaptive changes at transcriptional and translational levels. Changes in gene expression are controlled by post-translational modifications via chromatin remodeling. This review article focuses on the brain-region specific combinatorial or distinct epigenetic modifications that lead to METH-induced changes in gene expression. View Full-Text
Keywords: addiction; DNA methylation; epigenetics; HDAC inhibitors; histone acetylation; histone methylation; methamphetamine addiction; DNA methylation; epigenetics; HDAC inhibitors; histone acetylation; histone methylation; methamphetamine
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MDPI and ACS Style

Jayanthi, S.; McCoy, M.T.; Cadet, J.L. Epigenetic Regulatory Dynamics in Models of Methamphetamine-Use Disorder. Genes 2021, 12, 1614. https://doi.org/10.3390/genes12101614

AMA Style

Jayanthi S, McCoy MT, Cadet JL. Epigenetic Regulatory Dynamics in Models of Methamphetamine-Use Disorder. Genes. 2021; 12(10):1614. https://doi.org/10.3390/genes12101614

Chicago/Turabian Style

Jayanthi, Subramaniam, Michael T. McCoy, and Jean L. Cadet 2021. "Epigenetic Regulatory Dynamics in Models of Methamphetamine-Use Disorder" Genes 12, no. 10: 1614. https://doi.org/10.3390/genes12101614

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