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Regulation of mTORC1 by Upstream Stimuli

by 1,2,3 and 1,2,3,*
1
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
2
Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
3
Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
*
Author to whom correspondence should be addressed.
Genes 2020, 11(9), 989; https://doi.org/10.3390/genes11090989
Received: 30 July 2020 / Revised: 22 August 2020 / Accepted: 23 August 2020 / Published: 25 August 2020
(This article belongs to the Special Issue Cellular Growth Control by TOR Signaling)
The mammalian target of rapamycin (mTOR) is an evolutionary conserved Ser/Thr protein kinase that senses multiple upstream stimuli to control cell growth, metabolism, and autophagy. mTOR is the catalytic subunit of mTOR complex 1 (mTORC1). A significant amount of research has uncovered the signaling pathways regulated by mTORC1, and the involvement of these signaling cascades in human diseases like cancer, diabetes, and ageing. Here, we review advances in mTORC1 regulation by upstream stimuli. We specifically focus on how growth factors, amino acids, G-protein coupled receptors (GPCRs), phosphorylation, and small GTPases regulate mTORC1 activity and signaling. View Full-Text
Keywords: mTORC1; amino acids; G-protein coupled receptors; small GTPases; kinases; phosphorylation; cell growth; metabolism; and autophagy mTORC1; amino acids; G-protein coupled receptors; small GTPases; kinases; phosphorylation; cell growth; metabolism; and autophagy
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MDPI and ACS Style

Melick, C.H.; Jewell, J.L. Regulation of mTORC1 by Upstream Stimuli. Genes 2020, 11, 989. https://doi.org/10.3390/genes11090989

AMA Style

Melick CH, Jewell JL. Regulation of mTORC1 by Upstream Stimuli. Genes. 2020; 11(9):989. https://doi.org/10.3390/genes11090989

Chicago/Turabian Style

Melick, Chase H., and Jenna L. Jewell. 2020. "Regulation of mTORC1 by Upstream Stimuli" Genes 11, no. 9: 989. https://doi.org/10.3390/genes11090989

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