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Gut Microbiota between Environment and Genetic Background in Familial Mediterranean Fever (FMF)

1
Clinica Medica “Augusto Murri”, Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70124 Bari BA, Italy
2
Section of Medical Genetics, Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, 70124 Bari BA, Italy
3
Department of Medicine and Genetics, Division of Gastroenterology and Liver Diseases, Marion Bessin Liver Research Center, Einstein-Mount Sinai Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Genes 2020, 11(9), 1041; https://doi.org/10.3390/genes11091041
Received: 31 July 2020 / Revised: 26 August 2020 / Accepted: 31 August 2020 / Published: 3 September 2020
(This article belongs to the Special Issue Selected Papers From the Advanced Genetics Conference 2019)
The gastrointestinal tract hosts the natural reservoir of microbiota since birth. The microbiota includes various bacteria that establish a progressively mutual relationship with the host. Of note, the composition of gut microbiota is rather individual-specific and, normally, depends on both the host genotype and environmental factors. The study of the bacterial profile in the gut demonstrates that dominant and minor phyla are present in the gastrointestinal tract with bacterial density gradually increasing in oro-aboral direction. The cross-talk between bacteria and host within the gut strongly contributes to the host metabolism, to structural and protective functions. Dysbiosis can develop following aging, diseases, inflammatory status, and antibiotic therapy. Growing evidences show a possible link between the microbiota and Familial Mediterranean Fever (FMF), through a shift of the relative abundance in microbial species. To which extent such perturbations of the microbiota are relevant in driving the phenotypic manifestations of FMF with respect to genetic background, remains to be further investigated. View Full-Text
Keywords: amyloidosis; colchicine; inflammasome; interleukin-1b; MEFV amyloidosis; colchicine; inflammasome; interleukin-1b; MEFV
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MDPI and ACS Style

Di Ciaula, A.; Stella, A.; Bonfrate, L.; Wang, D.Q.H.; Portincasa, P. Gut Microbiota between Environment and Genetic Background in Familial Mediterranean Fever (FMF). Genes 2020, 11, 1041. https://doi.org/10.3390/genes11091041

AMA Style

Di Ciaula A, Stella A, Bonfrate L, Wang DQH, Portincasa P. Gut Microbiota between Environment and Genetic Background in Familial Mediterranean Fever (FMF). Genes. 2020; 11(9):1041. https://doi.org/10.3390/genes11091041

Chicago/Turabian Style

Di Ciaula, Agostino; Stella, Alessandro; Bonfrate, Leonilde; Wang, David Q.H.; Portincasa, Piero. 2020. "Gut Microbiota between Environment and Genetic Background in Familial Mediterranean Fever (FMF)" Genes 11, no. 9: 1041. https://doi.org/10.3390/genes11091041

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