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Advances in Genomics for Drug Development

Vir Biotechnology, Inc., San Francisco, CA 94158, USA
Author to whom correspondence should be addressed.
Genes 2020, 11(8), 942;
Received: 24 July 2020 / Revised: 4 August 2020 / Accepted: 13 August 2020 / Published: 15 August 2020
(This article belongs to the Section Technologies and Resources for Genetics)
Drug development (target identification, advancing drug leads to candidates for preclinical and clinical studies) can be facilitated by genetic and genomic knowledge. Here, we review the contribution of population genomics to target identification, the value of bulk and single cell gene expression analysis for understanding the biological relevance of a drug target, and genome-wide CRISPR editing for the prioritization of drug targets. In genomics, we discuss the different scope of genome-wide association studies using genotyping arrays, versus exome and whole genome sequencing. In transcriptomics, we discuss the information from drug perturbation and the selection of biomarkers. For CRISPR screens, we discuss target discovery, mechanism of action and the concept of gene to drug mapping. Harnessing genetic support increases the probability of drug developability and approval. View Full-Text
Keywords: druggability; loss-of-function; CRISPR druggability; loss-of-function; CRISPR
MDPI and ACS Style

Spreafico, R.; Soriaga, L.B.; Grosse, J.; Virgin, H.W.; Telenti, A. Advances in Genomics for Drug Development. Genes 2020, 11, 942.

AMA Style

Spreafico R, Soriaga LB, Grosse J, Virgin HW, Telenti A. Advances in Genomics for Drug Development. Genes. 2020; 11(8):942.

Chicago/Turabian Style

Spreafico, Roberto, Leah B. Soriaga, Johannes Grosse, Herbert W. Virgin, and Amalio Telenti. 2020. "Advances in Genomics for Drug Development" Genes 11, no. 8: 942.

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