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Review

Nuclear Regulation of Wnt/β-Catenin Signaling: It’s a Complex Situation

1
Department of Cell & Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA
2
Molecular Oncology Program, Division of Surgical Oncology, Dewitt Daughtry Family Department of Surgery, and Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
3
Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA
4
Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
*
Author to whom correspondence should be addressed.
Genes 2020, 11(8), 886; https://doi.org/10.3390/genes11080886
Received: 14 July 2020 / Revised: 29 July 2020 / Accepted: 31 July 2020 / Published: 4 August 2020
(This article belongs to the Special Issue Wnt Signaling in Development, Regeneration and Cancer)
Wnt signaling is an evolutionarily conserved metazoan cell communication pathway required for proper animal development. Of the myriad of signaling events that have been ascribed to cellular activation by Wnt ligands, the canonical Wnt/β-catenin pathway has been the most studied and best understood. Misregulation of Wnt/β-catenin signaling has been implicated in developmental defects in the embryo and major diseases in the adult. Despite the latter, no drugs that inhibit the Wnt/β-catenin pathway have been approved by the FDA. In this review, we explore the least understood step in the Wnt/β-catenin pathway—nuclear regulation of Wnt target gene transcription. We initially describe our current understanding of the importation of β-catenin into the nucleus. We then focus on the mechanism of action of the major nuclear proteins implicated in driving gene transcription. Finally, we explore the concept of a nuclear Wnt enhanceosome and propose a modified model that describes the necessary components for the transcription of Wnt target genes. View Full-Text
Keywords: Wnt/β-catenin signaling; nuclear regulation; TCF/LEF; TLE; Pygopus; BCL9; enhanceosome Wnt/β-catenin signaling; nuclear regulation; TCF/LEF; TLE; Pygopus; BCL9; enhanceosome
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MDPI and ACS Style

Anthony, C.C.; Robbins, D.J.; Ahmed, Y.; Lee, E. Nuclear Regulation of Wnt/β-Catenin Signaling: It’s a Complex Situation. Genes 2020, 11, 886. https://doi.org/10.3390/genes11080886

AMA Style

Anthony CC, Robbins DJ, Ahmed Y, Lee E. Nuclear Regulation of Wnt/β-Catenin Signaling: It’s a Complex Situation. Genes. 2020; 11(8):886. https://doi.org/10.3390/genes11080886

Chicago/Turabian Style

Anthony, Christin C., David J. Robbins, Yashi Ahmed, and Ethan Lee. 2020. "Nuclear Regulation of Wnt/β-Catenin Signaling: It’s a Complex Situation" Genes 11, no. 8: 886. https://doi.org/10.3390/genes11080886

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