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Glia and Neural Stem and Progenitor Cells of the Healthy and Ischemic Brain: The Workplace for the Wnt Signaling Pathway

1
Institute of Experimental Medicine, Czech Academy of Sciences, 1083 Videnska, 142 20 Prague, Czech Republic
2
Second Faculty of Medicine, Charles University, 84 V Uvalu, 150 06 Prague, Czech Republic
3
Institute of Molecular Genetics, Czech Academy of Sciences, 1083 Videnska, 142 20 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Genes 2020, 11(7), 804; https://doi.org/10.3390/genes11070804
Received: 29 June 2020 / Revised: 10 July 2020 / Accepted: 15 July 2020 / Published: 16 July 2020
(This article belongs to the Special Issue Wnt Signaling in Development, Regeneration and Cancer)
Wnt signaling plays an important role in the self-renewal, fate-commitment and survival of the neural stem/progenitor cells (NS/PCs) of the adult central nervous system (CNS). Ischemic stroke impairs the proper functioning of the CNS and, therefore, active Wnt signaling may prevent, ameliorate, or even reverse the negative effects of ischemic brain injury. In this review, we provide the current knowledge of Wnt signaling in the adult CNS, its status in diverse cell types, and the Wnt pathway’s impact on the properties of NS/PCs and glial cells in the context of ischemic injury. Finally, we summarize promising strategies that might be considered for stroke therapy, and we outline possible future directions of the field. View Full-Text
Keywords: Wnt signaling; central nervous system; neural stem/progenitor cell; glia; subventricular zone; subgranular zone; ischemia; stroke; adult neurogenesis Wnt signaling; central nervous system; neural stem/progenitor cell; glia; subventricular zone; subgranular zone; ischemia; stroke; adult neurogenesis
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MDPI and ACS Style

Knotek, T.; Janeckova, L.; Kriska, J.; Korinek, V.; Anderova, M. Glia and Neural Stem and Progenitor Cells of the Healthy and Ischemic Brain: The Workplace for the Wnt Signaling Pathway. Genes 2020, 11, 804. https://doi.org/10.3390/genes11070804

AMA Style

Knotek T, Janeckova L, Kriska J, Korinek V, Anderova M. Glia and Neural Stem and Progenitor Cells of the Healthy and Ischemic Brain: The Workplace for the Wnt Signaling Pathway. Genes. 2020; 11(7):804. https://doi.org/10.3390/genes11070804

Chicago/Turabian Style

Knotek, Tomas, Lucie Janeckova, Jan Kriska, Vladimir Korinek, and Miroslava Anderova. 2020. "Glia and Neural Stem and Progenitor Cells of the Healthy and Ischemic Brain: The Workplace for the Wnt Signaling Pathway" Genes 11, no. 7: 804. https://doi.org/10.3390/genes11070804

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