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Epigenetics as an Evolutionary Tool for Centromere Flexibility

1
Istituto Pasteur Italia, Dipartimento di Biologia e Biotecnologie “Charles Darwin”, “Sapienza” University of Rome, 00185 Rome, Italy
2
Laboratory of Chromosome and Cell Biology, The Rockefeller University, New York, NY 10065, USA
*
Author to whom correspondence should be addressed.
Genes 2020, 11(7), 809; https://doi.org/10.3390/genes11070809
Received: 17 June 2020 / Revised: 11 July 2020 / Accepted: 13 July 2020 / Published: 16 July 2020
(This article belongs to the Special Issue The Role of Centromeres in Genome Stability)
Centromeres are the complex structures responsible for the proper segregation of chromosomes during cell division. Structural or functional alterations of the centromere cause aneuploidies and other chromosomal aberrations that can induce cell death with consequences on health and survival of the organism as a whole. Because of their essential function in the cell, centromeres have evolved high flexibility and mechanisms of tolerance to preserve their function following stress, whether it is originating from within or outside the cell. Here, we review the main epigenetic mechanisms of centromeres’ adaptability to preserve their functional stability, with particular reference to neocentromeres and holocentromeres. The centromere position can shift in response to altered chromosome structures, but how and why neocentromeres appear in a given chromosome region are still open questions. Models of neocentromere formation developed during the last few years will be hereby discussed. Moreover, we will discuss the evolutionary significance of diffuse centromeres (holocentromeres) in organisms such as nematodes. Despite the differences in DNA sequences, protein composition and centromere size, all of these diverse centromere structures promote efficient chromosome segregation, balancing genome stability and adaptability, and ensuring faithful genome inheritance at each cellular generation. View Full-Text
Keywords: centromere; neocentromere; holocentromere; CENP-A; repetitive sequences; centromere evolution centromere; neocentromere; holocentromere; CENP-A; repetitive sequences; centromere evolution
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MDPI and ACS Style

Leo, L.; Marchetti, M.; Giunta, S.; Fanti, L. Epigenetics as an Evolutionary Tool for Centromere Flexibility. Genes 2020, 11, 809. https://doi.org/10.3390/genes11070809

AMA Style

Leo L, Marchetti M, Giunta S, Fanti L. Epigenetics as an Evolutionary Tool for Centromere Flexibility. Genes. 2020; 11(7):809. https://doi.org/10.3390/genes11070809

Chicago/Turabian Style

Leo, Laura, Marcella Marchetti, Simona Giunta, and Laura Fanti. 2020. "Epigenetics as an Evolutionary Tool for Centromere Flexibility" Genes 11, no. 7: 809. https://doi.org/10.3390/genes11070809

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