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10.3390/genes11070776
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Article

Pro12Ala PPAR-γ2 and +294T/C PPAR-δ Polymorphisms and Association with Metabolic Traits in Teenagers from Northern Mexico

by
Martín A. Carrillo-Venzor
1,
Nancy R. Erives-Anchondo
1,
Janette G. Moreno-González
1,
Verónica Moreno-Brito
1,
Angel Licón-Trillo
1,
Everardo González-Rodríguez
1,
Pilar del Carmen Hernández-Rodríguez
2,
Sandra A. Reza-López
1,
Verónica Loera-Castañeda
3 and
Irene Leal-Berumen
1,*
1
Faculty of Medicine and Biomedical Sciences, Autonomous University of Chihuahua, Circuito Universitario, Campus II, Chihuahua 31109, Mexico
2
Faculty of Chemical Sciences, Autonomous University of Chihuahua, Circuito Universitario, Campus II, Chihuahua 31109, Mexico
3
CIIDIR-IPN, Durango 34220, Mexico
*
Author to whom correspondence should be addressed.
Genes 2020, 11(7), 776; https://doi.org/10.3390/genes11070776
Submission received: 12 May 2020 / Revised: 1 July 2020 / Accepted: 7 July 2020 / Published: 10 July 2020
(This article belongs to the Section Human Genomics and Genetic Diseases)
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Abstract

Peroxisome proliferator-activated receptors (PPARs) play roles in glucose and lipid metabolism regulation. Pro12Ala PPAR-γ2 and +294T/C PPAR-δ have been associated with dyslipidemia, hyperglycemia and high body mass index (BMI). We compared metabolic traits and determined associations with Pro12Ala PPAR-γ2 or +294T/C PPAR-δ polymorphism among teenagers from different ethnicity. Four hundred and twelve samples with previous biochemical and biometric measurements were used. Genomic DNA from peripheral blood was extracted and analyzed by end-point PCR for Pro12Ala PPAR-γ2. The +294T/C PPAR-δ PCR product was also digested with Bsl I. Two genotype groups were formed: major allele homozygous and minor allele carriers. Pro12Ala PPAR-γ2 G minor allele frequencies were: 10% in Mestizo-1, 19% in Mestizo-2, 23% in Tarahumara, 12% in Mennonite, and 17% in the total studied population. The +294T/C PPAR-δ C minor allele frequencies were: 18% in Mestizo-1, 20% in Mestizo-2, 6% in Tarahumara, 13% in Mennonite, and 12% in the total studied population. Teenagers with PPAR-γ2 G allele showed a greater risk for either high waist/height ratio or low high-density lipoprotein; and, also had lower total cholesterol. Whereas, PPAR-γ2 G allele showed lower overweight/obesity phenotype (BMI Z-score) frequency, PPAR-δ C allele was a risk factor for it. Metabolic traits were associated with both PPAR polymorphisms.
Keywords: Pro12Ala; +294T/C; PPARs polymorphisms; metabolic traits; allele frequencies; major/minor allele; genotypes Pro12Ala; +294T/C; PPARs polymorphisms; metabolic traits; allele frequencies; major/minor allele; genotypes

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MDPI and ACS Style

Carrillo-Venzor, M.A.; Erives-Anchondo, N.R.; Moreno-González, J.G.; Moreno-Brito, V.; Licón-Trillo, A.; González-Rodríguez, E.; Hernández-Rodríguez, P.d.C.; Reza-López, S.A.; Loera-Castañeda, V.; Leal-Berumen, I. Pro12Ala PPAR-γ2 and +294T/C PPAR-δ Polymorphisms and Association with Metabolic Traits in Teenagers from Northern Mexico. Genes 2020, 11, 776. https://doi.org/10.3390/genes11070776

AMA Style

Carrillo-Venzor MA, Erives-Anchondo NR, Moreno-González JG, Moreno-Brito V, Licón-Trillo A, González-Rodríguez E, Hernández-Rodríguez PdC, Reza-López SA, Loera-Castañeda V, Leal-Berumen I. Pro12Ala PPAR-γ2 and +294T/C PPAR-δ Polymorphisms and Association with Metabolic Traits in Teenagers from Northern Mexico. Genes. 2020; 11(7):776. https://doi.org/10.3390/genes11070776

Chicago/Turabian Style

Carrillo-Venzor, Martín A., Nancy R. Erives-Anchondo, Janette G. Moreno-González, Verónica Moreno-Brito, Angel Licón-Trillo, Everardo González-Rodríguez, Pilar del Carmen Hernández-Rodríguez, Sandra A. Reza-López, Verónica Loera-Castañeda, and Irene Leal-Berumen. 2020. "Pro12Ala PPAR-γ2 and +294T/C PPAR-δ Polymorphisms and Association with Metabolic Traits in Teenagers from Northern Mexico" Genes 11, no. 7: 776. https://doi.org/10.3390/genes11070776

APA Style

Carrillo-Venzor, M. A., Erives-Anchondo, N. R., Moreno-González, J. G., Moreno-Brito, V., Licón-Trillo, A., González-Rodríguez, E., Hernández-Rodríguez, P. d. C., Reza-López, S. A., Loera-Castañeda, V., & Leal-Berumen, I. (2020). Pro12Ala PPAR-γ2 and +294T/C PPAR-δ Polymorphisms and Association with Metabolic Traits in Teenagers from Northern Mexico. Genes, 11(7), 776. https://doi.org/10.3390/genes11070776

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