TLR4 Polymorphism, Nasopharyngeal Bacterial Colonization, and the Development of Childhood Asthma: A Prospective Birth-Cohort Study in Finnish Children

Teräsjärvi, Johanna T.; Toivonen, Laura; Vuononvirta, Juho; Mertsola, Jussi; Peltola, Ville; He, Qiushui

doi:10.3390/genes11070768

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TLR4 Polymorphism, Nasopharyngeal Bacterial Colonization, and the Development of Childhood Asthma: A Prospective Birth-Cohort Study in Finnish Children

Johanna T. Teräsjärvi

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² and

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Institute of Biomedicine, Research Center for Infections and Immunity, University of Turku, 20520 Turku, Finland

Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, 20520 Turku, Finland

William Harvey Heart Centre, Barts & the London School of Medicine & Dentistry, Queen Mary University of London, London EC1M 6BQ, UK

⁴

Department of Medical Microbiology, Capital Medical University, Beijing 100069, China

Author to whom correspondence should be addressed.

Genes 2020, 11(7), 768; https://doi.org/10.3390/genes11070768

Received: 22 June 2020 / Revised: 30 June 2020 / Accepted: 3 July 2020 / Published: 8 July 2020

(This article belongs to the Special Issue Host Genetics in Susceptibility to Infectious Diseases)

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Abstract

We aimed to explore the role of TLR4 (rs4986790) polymorphism in the nasopharyngeal (NP) bacterial colonization and its consequent impact on the development of childhood asthma. A semi-quantitative culture of NP swabs was performed on 473 children at 2 months of age and on 213 children at 13 months of age. TLR4 polymorphism was analyzed for 396 children. Children were followed from birth to the age of 7.5 years and the final outcome was physician-diagnosed asthma. The associations between TLR4 genotype, bacterial colonization, and asthma were analyzed. Children with TLR4 AG or GG genotype were more often colonized with Moraxella catarrhalis at 2 months of age (p = 0.009) and Haemophilus influenzae at 13 months of age (p = 0.018). Children who were colonized with H. influenzae at 13 months of age had a significantly higher risk of later development of asthma (p = 0.004). M. catarrhalis or H. Influenzae colonization at 2 months of age or TLR4 genotype Asp299Gly were not associated with the development of childhood asthma. TLR4 Asp299Gly polymorphism was associated with an increased risk of colonization of M. catarrhalis and H. influenzae in children. The colonization with H. influenzae at 13 months of age was associated with a higher risk of later development of childhood asthma. View Full-Text

Keywords: TLR4; nasopharyngeal bacterial colonization; asthma; Moraxella catarrhalis; Haemophilus influenzae; childhood asthma

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Teräsjärvi, J.T.; Toivonen, L.; Vuononvirta, J.; Mertsola, J.; Peltola, V.; He, Q. TLR4 Polymorphism, Nasopharyngeal Bacterial Colonization, and the Development of Childhood Asthma: A Prospective Birth-Cohort Study in Finnish Children. Genes 2020, 11, 768. https://doi.org/10.3390/genes11070768

AMA Style

Teräsjärvi JT, Toivonen L, Vuononvirta J, Mertsola J, Peltola V, He Q. TLR4 Polymorphism, Nasopharyngeal Bacterial Colonization, and the Development of Childhood Asthma: A Prospective Birth-Cohort Study in Finnish Children. Genes. 2020; 11(7):768. https://doi.org/10.3390/genes11070768

Chicago/Turabian Style

Teräsjärvi, Johanna T., Laura Toivonen, Juho Vuononvirta, Jussi Mertsola, Ville Peltola, and Qiushui He. 2020. "TLR4 Polymorphism, Nasopharyngeal Bacterial Colonization, and the Development of Childhood Asthma: A Prospective Birth-Cohort Study in Finnish Children" Genes 11, no. 7: 768. https://doi.org/10.3390/genes11070768

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TLR4 Polymorphism, Nasopharyngeal Bacterial Colonization, and the Development of Childhood Asthma: A Prospective Birth-Cohort Study in Finnish Children

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