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Open AccessFeature PaperReview

Precision and Personalized Medicine: How Genomic Approach Improves the Management of Cardiovascular and Neurodegenerative Disease

1
Clinical Research and Innovation, Clinica Montevergine S.p.A., 83013 Mercogliano, Italy
2
Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, 84084 Baronissi, Italy
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Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, 84084 Baronissi, Italy
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Unit of Cardiology, Clinica Montevergine S.p.A., 83013 Mercogliano, Italy
*
Author to whom correspondence should be addressed.
Genes 2020, 11(7), 747; https://doi.org/10.3390/genes11070747
Received: 18 June 2020 / Revised: 30 June 2020 / Accepted: 2 July 2020 / Published: 6 July 2020
Life expectancy has gradually grown over the last century. This has deeply affected healthcare costs, since the growth of an aging population is correlated to the increasing burden of chronic diseases. This represents the interesting challenge of how to manage patients with chronic diseases in order to improve health care budgets. Effective primary prevention could represent a promising route. To this end, precision, together with personalized medicine, are useful instruments in order to investigate pathological processes before the appearance of clinical symptoms and to guide physicians to choose a targeted therapy to manage the patient. Cardiovascular and neurodegenerative diseases represent suitable models for taking full advantage of precision medicine technologies applied to all stages of disease development. The availability of high technology incorporating artificial intelligence and advancement progress made in the field of biomedical research have been substantial to understand how genes, epigenetic modifications, aging, nutrition, drugs, microbiome and other environmental factors can impact health and chronic disorders. The aim of the present review is to address how precision and personalized medicine can bring greater clarity to the clinical and biological complexity of these types of disorders associated with high mortality, involving tremendous health care costs, by describing in detail the methods that can be applied. This might offer precious tools for preventive strategies and possible clues on the evolution of the disease and could help in predicting morbidity, mortality and detecting chronic disease indicators much earlier in the disease course. This, of course, will have a major effect on both improving the quality of care and quality of life of the patients and reducing time efforts and healthcare costs. View Full-Text
Keywords: precision medicine; personalized medicine; clinical application; genomics precision medicine; personalized medicine; clinical application; genomics
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MDPI and ACS Style

Strianese, O.; Rizzo, F.; Ciccarelli, M.; Galasso, G.; D’Agostino, Y.; Salvati, A.; Del Giudice, C.; Tesorio, P.; Rusciano, M.R. Precision and Personalized Medicine: How Genomic Approach Improves the Management of Cardiovascular and Neurodegenerative Disease. Genes 2020, 11, 747. https://doi.org/10.3390/genes11070747

AMA Style

Strianese O, Rizzo F, Ciccarelli M, Galasso G, D’Agostino Y, Salvati A, Del Giudice C, Tesorio P, Rusciano MR. Precision and Personalized Medicine: How Genomic Approach Improves the Management of Cardiovascular and Neurodegenerative Disease. Genes. 2020; 11(7):747. https://doi.org/10.3390/genes11070747

Chicago/Turabian Style

Strianese, Oriana; Rizzo, Francesca; Ciccarelli, Michele; Galasso, Gennaro; D’Agostino, Ylenia; Salvati, Annamaria; Del Giudice, Carmine; Tesorio, Paola; Rusciano, Maria R. 2020. "Precision and Personalized Medicine: How Genomic Approach Improves the Management of Cardiovascular and Neurodegenerative Disease" Genes 11, no. 7: 747. https://doi.org/10.3390/genes11070747

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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