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RECQ1 Helicase in Genomic Stability and Cancer

by 1 and 1,2,*
1
Department of Biochemistry and Molecular Biology, College of Medicine, Howard University, 520 W Street, NW, Washington, DC 20059, USA
2
National Human Genome Center, College of Medicine, Howard University, 520 W Street, NW, Washington, DC 20059, USA
*
Author to whom correspondence should be addressed.
Genes 2020, 11(6), 622; https://doi.org/10.3390/genes11060622
Received: 11 May 2020 / Revised: 1 June 2020 / Accepted: 3 June 2020 / Published: 5 June 2020
(This article belongs to the Special Issue DNA Helicases: Mechanisms, Biological Pathways, and Disease Relevance)
RECQ1 (also known as RECQL or RECQL1) belongs to the RecQ family of DNA helicases, members of which are linked with rare genetic diseases of cancer predisposition in humans. RECQ1 is implicated in several cellular processes, including DNA repair, cell cycle and growth, telomere maintenance, and transcription. Earlier studies have demonstrated a unique requirement of RECQ1 in ensuring chromosomal stability and suggested its potential involvement in tumorigenesis. Recent reports have suggested that RECQ1 is a potential breast cancer susceptibility gene, and missense mutations in this gene contribute to familial breast cancer development. Here, we provide a framework for understanding how the genetic or functional loss of RECQ1 might contribute to genomic instability and cancer. View Full-Text
Keywords: helicase; replication; DNA repair; G4; transcription; genomic stability; breast cancer; cancer helicase; replication; DNA repair; G4; transcription; genomic stability; breast cancer; cancer
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MDPI and ACS Style

Debnath, S.; Sharma, S. RECQ1 Helicase in Genomic Stability and Cancer. Genes 2020, 11, 622. https://doi.org/10.3390/genes11060622

AMA Style

Debnath S, Sharma S. RECQ1 Helicase in Genomic Stability and Cancer. Genes. 2020; 11(6):622. https://doi.org/10.3390/genes11060622

Chicago/Turabian Style

Debnath, Subrata, and Sudha Sharma. 2020. "RECQ1 Helicase in Genomic Stability and Cancer" Genes 11, no. 6: 622. https://doi.org/10.3390/genes11060622

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