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Comparative Genomics of Two New HF1-like Haloviruses

Computational Biology Group, Max-Planck-Institute of Biochemistry, 82152 Martinsried, Germany
Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville 3010, Australia
Biodiversity Research Center, Academia Sinica, Nankang, Taipei 115, Taiwan
Department of Microbiology, Monash University, Clayton Campus, Victoria 3800, Australia
Author to whom correspondence should be addressed.
Genes 2020, 11(4), 405;
Received: 3 March 2020 / Revised: 3 April 2020 / Accepted: 6 April 2020 / Published: 8 April 2020
(This article belongs to the Special Issue Molecular Genetics and Genomics of Halophilic Microorganisms)
Few genomes of the HF1-group of viruses are currently available, and further examples would enhance the understanding of their evolution, improve their gene annotation, and assist in understanding gene function and regulation. Two novel HF1-group haloviruses, Serpecor1 and Hardycor2, were recovered from widely separated hypersaline lakes in Australia. Both are myoviruses with linear dsDNA genomes and infect the haloarchaeon Halorubrum coriense. Both genomes possess long, terminal direct repeat (TDR) sequences (320 bp for Serpecor1 and 306 bp for Hardycor2). The Serpecor1 genome is 74,196 bp in length, 57.0% G+C, and has 126 annotated coding sequences (CDS). Hardycor2 has a genome of 77,342 bp, 55.6% G+C, and 125 annotated CDS. They show high nucleotide sequence similarity to each other (78%) and with HF1 (>75%), and carry similar intergenic repeat (IR) sequences to those originally described in HF1 and HF2. Hardycor2 carries a DNA methyltransferase gene in the same genomic neighborhood as the methyltransferase genes of HF1, HF2 and HRTV-5, but is in the opposite orientation, and the inferred proteins are only distantly related. Comparative genomics allowed us to identify the candidate genes mediating cell attachment. The genomes of Serpecor1 and Hardycor2 encode numerous small proteins carrying one or more CxxC motifs, a signature feature of zinc-finger domain proteins that are known to participate in diverse biomolecular interactions. View Full-Text
Keywords: archaea; haloarchaea; halovirus; virus genome; Halorubrum; Haloferax archaea; haloarchaea; halovirus; virus genome; Halorubrum; Haloferax
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MDPI and ACS Style

Dyall-Smith, M.; Tang, S.-L.; Russ, B.; Chiang, P.-W.; Pfeiffer, F. Comparative Genomics of Two New HF1-like Haloviruses. Genes 2020, 11, 405.

AMA Style

Dyall-Smith M, Tang S-L, Russ B, Chiang P-W, Pfeiffer F. Comparative Genomics of Two New HF1-like Haloviruses. Genes. 2020; 11(4):405.

Chicago/Turabian Style

Dyall-Smith, Mike, Sen-Lin Tang, Brendan Russ, Pei-Wen Chiang, and Friedhelm Pfeiffer. 2020. "Comparative Genomics of Two New HF1-like Haloviruses" Genes 11, no. 4: 405.

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