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Review

Experimental Models to Study Autism Spectrum Disorders: hiPSCs, Rodents and Zebrafish

1
Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Campus de Lugo, 27002 Lugo, Spain
2
Genomic Medicine Group, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, 15706 Santiago de Compostela, Spain
3
Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), CIMUS, Universidade de Santiago de Compostela, 15706 Santiago de Compostela, Spain
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Genes 2020, 11(11), 1376; https://doi.org/10.3390/genes11111376
Received: 9 October 2020 / Revised: 26 October 2020 / Accepted: 18 November 2020 / Published: 20 November 2020
(This article belongs to the Special Issue Zebrafish Animal Models)
Autism Spectrum Disorders (ASD) affect around 1.5% of the global population, which manifest alterations in communication and socialization, as well as repetitive behaviors or restricted interests. ASD is a complex disorder with known environmental and genetic contributors; however, ASD etiology is far from being clear. In the past decades, many efforts have been put into developing new models to study ASD, both in vitro and in vivo. These models have a lot of potential to help to validate some of the previously associated risk factors to the development of the disorder, and to test new potential therapies that help to alleviate ASD symptoms. The present review is focused on the recent advances towards the generation of models for the study of ASD, which would be a useful tool to decipher the bases of the disorder, as well as to conduct drug screenings that hopefully lead to the identification of useful compounds to help patients deal with the symptoms of ASD. View Full-Text
Keywords: autism spectrum disorders (ASD); animal models; cellular models; genome editing; human induced pluripotent stem cells (hiPSCs); neurodevelopmental disorders (NDDs); rodents; zebrafish autism spectrum disorders (ASD); animal models; cellular models; genome editing; human induced pluripotent stem cells (hiPSCs); neurodevelopmental disorders (NDDs); rodents; zebrafish
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MDPI and ACS Style

Pensado-López, A.; Veiga-Rúa, S.; Carracedo, Á.; Allegue, C.; Sánchez, L. Experimental Models to Study Autism Spectrum Disorders: hiPSCs, Rodents and Zebrafish. Genes 2020, 11, 1376. https://doi.org/10.3390/genes11111376

AMA Style

Pensado-López A, Veiga-Rúa S, Carracedo Á, Allegue C, Sánchez L. Experimental Models to Study Autism Spectrum Disorders: hiPSCs, Rodents and Zebrafish. Genes. 2020; 11(11):1376. https://doi.org/10.3390/genes11111376

Chicago/Turabian Style

Pensado-López, Alba, Sara Veiga-Rúa, Ángel Carracedo, Catarina Allegue, and Laura Sánchez. 2020. "Experimental Models to Study Autism Spectrum Disorders: hiPSCs, Rodents and Zebrafish" Genes 11, no. 11: 1376. https://doi.org/10.3390/genes11111376

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