Contribution of Known Genetic Risk Variants to Dyslipidemias and Type 2 Diabetes in Mexico: A Population-Based Nationwide Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. 2000. National Health Survey
2.2. Genotyping and Quality Control Procedures
2.3. Polygenic Risk Score
2.4. Population Stratification Control
2.5. Statistical Analyses
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Variable | Raw | Expansion |
---|---|---|
N | 1627 | 1,920,663 |
Age (years) | 38.21 ± 14.84 | 35.21 ± 13.97 |
Sex (% females) | 32.49 | 50.0 |
Diabetic status (%) | 13 | 8.0 |
Systolic blood pressure (mmHg) | 120.81 ± 15.71 | 120.8 ± 14.99 |
Diastolic blood pressure (mmHg) | 79.51 ± 11.4 | 79.10 ± 11.36 |
BMI (kg/m2) | 27.18 ± 5.38 | 26.76 ± 5.20 |
Waist circumference (cm) | 93.26 ± 15.7 | 92.16 ± 15.85 |
Glucose (mg/dL) | 74 [65–86] | 74 [65–85] |
Creatinine (mg/dL) | 0.9 [0.8–1] | 0.9 [0.8–1.1] |
Total cholesterol (mg/dL) | 190 [164–223] | 183 [159–219] |
Triglycerides (mg/dL) | 146 [98–212] | 131 [87–192] |
HDL cholesterol (mg/dL) | 43 [37–52] | 41 [34–48] |
LDL cholesterol (mg/dL) | 114 [94–139] | 111 [94–136] |
Native American ancestry (%) | 61.9 [49.1–77.3] | 62.9 [50.4–76.8] |
Variable | Euglycemia | Diabetes | Normolipidemia | Dyslipidemia |
---|---|---|---|---|
N | 1,095,837 | 95,177 | 643,776 | 1,271,329 |
Age (years) | 34.17 ± 13.45 | 50.30 ± 14.85 a | 31.48 ± 13.06 | 37.06 ± 14.01 b |
Sex (% females) | 48.3 | 68.5 a | 59.85 | 45.03 b |
Diabetic status (%) | 0 | 100 | 6.0 | 8.9 |
Dyslipidemia status (%) | 70.6 | 78.7 | 0 | 100 |
Systolic blood pressure (mmHg) | 120.9 ± 14.99 | 129.4 ± 17.67 a | 116.22 ± 12.25 | 123.14 ± 15.73 b |
Diastolic blood pressure (mmHg) | 79.10 ± 14.96 | 81.87 ± 11.97 | 76.17 ± 9.32 | 80.62 ± 12 b |
BMI (kg/m2) | 26.79 ± 5.36 | 29.43 ± 4.98 a | 25.26 ± 4.99 | 27.53 ± 5.1 b |
Waist circumference (cm) | 92.75 ± 16.33 | 101.19 ± 14 a | 87.08 ± 14.50 | 94.71 ± 15.9 b |
Glucose (mg/dL) | 75 [66–85] | 190 [136–255] a | 72 [63–82] | 75 [67–87] b |
Creatinine (mg/dL) | 0.9 [0.8–1.1] | 0.9 [0.8–1.0] | 0.9 [0.8–1.0] | 0.95 [0.8–1.1] b |
Total cholesterol (mg/dL) | 187 [161–222] | 200 [176–242.3] a | 170 [154.6–182] | 207 [166–232.1] b |
Triglycerides (mg/dL) | 144 [97–207] | 188.2 [139.1–243.5] a | 94 [72–116.9] | 175 [125–238] b |
HDL cholesterol (mg/dL) | 41 [34–48] | 40 [33–45] | 46 [40–53] | 40 [32–48] b |
LDL cholesterol (mg/dL) | 112.3 [96–140] | 124.5 [107–152.7] | 102 [89–114] | 127 [101–150] b |
Native American ancestry (%) | 58.2 [47–72.8] | 64.8 [53.9–80.4] a | 64.5 [53.2–81.4] | 61.5 [49.5–76] |
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Huerta-Chagoya, A.; Moreno-Macías, H.; Sevilla-González, M.; Rodríguez-Guillén, R.; Ordóñez-Sánchez, M.L.; Gómez-Velasco, D.; Muñóz-Hernández, L.; Segura-Kato, Y.; Arellano-Campos, O.; Cruz-Bautista, I.; et al. Contribution of Known Genetic Risk Variants to Dyslipidemias and Type 2 Diabetes in Mexico: A Population-Based Nationwide Study. Genes 2020, 11, 114. https://doi.org/10.3390/genes11010114
Huerta-Chagoya A, Moreno-Macías H, Sevilla-González M, Rodríguez-Guillén R, Ordóñez-Sánchez ML, Gómez-Velasco D, Muñóz-Hernández L, Segura-Kato Y, Arellano-Campos O, Cruz-Bautista I, et al. Contribution of Known Genetic Risk Variants to Dyslipidemias and Type 2 Diabetes in Mexico: A Population-Based Nationwide Study. Genes. 2020; 11(1):114. https://doi.org/10.3390/genes11010114
Chicago/Turabian StyleHuerta-Chagoya, Alicia, Hortensia Moreno-Macías, Magdalena Sevilla-González, Rosario Rodríguez-Guillén, María L. Ordóñez-Sánchez, Donají Gómez-Velasco, Liliana Muñóz-Hernández, Yayoi Segura-Kato, Olimpia Arellano-Campos, Ivette Cruz-Bautista, and et al. 2020. "Contribution of Known Genetic Risk Variants to Dyslipidemias and Type 2 Diabetes in Mexico: A Population-Based Nationwide Study" Genes 11, no. 1: 114. https://doi.org/10.3390/genes11010114
APA StyleHuerta-Chagoya, A., Moreno-Macías, H., Sevilla-González, M., Rodríguez-Guillén, R., Ordóñez-Sánchez, M. L., Gómez-Velasco, D., Muñóz-Hernández, L., Segura-Kato, Y., Arellano-Campos, O., Cruz-Bautista, I., Aguilar-Salinas, C. A., & Tusié-Luna, T. (2020). Contribution of Known Genetic Risk Variants to Dyslipidemias and Type 2 Diabetes in Mexico: A Population-Based Nationwide Study. Genes, 11(1), 114. https://doi.org/10.3390/genes11010114