Association of Vitamin D Pathway Genetic Variation and Thyroid Cancer
AbstractVitamin D is mostly known for its role in bone and calcium metabolism. However, studies have suggested that it also has inhibitory effects on tumor development and progression. Genetic variants close to genes that encode crucial enzymes for the synthesis (DHCR7 rs12785878), metabolism (CYP2R1 rs2060793) and degradation (CYP24A1 rs6013897) of vitamin D have been associated with serum levels of vitamin D. The aim of this case-control study was to determine the effect of these variants in the vitamin D pathway on the susceptibility to thyroid cancer. Five hundred patients with differentiated thyroid cancer and 500 controls were genotyped for the DHCR7 rs12785878, CYP2R1 rs2060793, and CYP24A1 rs6013897 variants. Genotype and allele frequencies were compared between patients and controls. The DHCR7 rs12785878 minor allele was associated with thyroid cancer under an additive (OR 1.38, 95% CI 1.15–1.65, p = 0.0004) and codominant (OR 1.88, 95% CI 1.30–2.74, p = 0.0021) model. These findings suggest that DHCR7 polymorphisms may be associated with an increased risk of thyroid cancer due to an effect of this gene on circulating vitamin D levels. View Full-Text
Share & Cite This Article
Carvalho, I.S.; Gonçalves, C.I.; Almeida, J.T.; Azevedo, T.; Martins, T.; Rodrigues, F.J.; Lemos, M.C. Association of Vitamin D Pathway Genetic Variation and Thyroid Cancer. Genes 2019, 10, 572.
Carvalho IS, Gonçalves CI, Almeida JT, Azevedo T, Martins T, Rodrigues FJ, Lemos MC. Association of Vitamin D Pathway Genetic Variation and Thyroid Cancer. Genes. 2019; 10(8):572.Chicago/Turabian Style
Carvalho, Isabel S.; Gonçalves, Catarina I.; Almeida, Joana T.; Azevedo, Teresa; Martins, Teresa; Rodrigues, Fernando J.; Lemos, Manuel C. 2019. "Association of Vitamin D Pathway Genetic Variation and Thyroid Cancer." Genes 10, no. 8: 572.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.