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Integrative rDNAomics—Importance of the Oldest Repetitive Fraction of the Eukaryote Genome

Faculty of Science, Department of Biology, University of Hradec Králové, 500 03 Hradec Králové, Czech Republic
Genes 2019, 10(5), 345; https://doi.org/10.3390/genes10050345
Received: 3 February 2019 / Revised: 17 April 2019 / Accepted: 25 April 2019 / Published: 7 May 2019
(This article belongs to the Special Issue Repetitive DNA Sequences)
Nuclear ribosomal RNA (rRNA) genes represent the oldest repetitive fraction universal to all eukaryotic genomes. Their deeply anchored universality and omnipresence during eukaryotic evolution reflects in multiple roles and functions reaching far beyond ribosomal synthesis. Merely the copy number of non-transcribed rRNA genes is involved in mechanisms governing e.g., maintenance of genome integrity and control of cellular aging. Their copy number can vary in response to environmental cues, in cellular stress sensing, in development of cancer and other diseases. While reaching hundreds of copies in humans, there are records of up to 20,000 copies in fish and frogs and even 400,000 copies in ciliates forming thus a literal subgenome or an rDNAome within the genome. From the compositional and evolutionary dynamics viewpoint, the precursor 45S rDNA represents universally GC-enriched, highly recombining and homogenized regions. Hence, it is not accidental that both rDNA sequence and the corresponding rRNA secondary structure belong to established phylogenetic markers broadly used to infer phylogeny on multiple taxonomical levels including species delimitation. However, these multiple roles of rDNAs have been treated and discussed as being separate and independent from each other. Here, I aim to address nuclear rDNAs in an integrative approach to better assess the complexity of rDNA importance in the evolutionary context. View Full-Text
Keywords: nuclear rDNA; rRNA; GC-content; secondary structure; nucleolus nuclear rDNA; rRNA; GC-content; secondary structure; nucleolus
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MDPI and ACS Style

Symonová, R. Integrative rDNAomics—Importance of the Oldest Repetitive Fraction of the Eukaryote Genome. Genes 2019, 10, 345. https://doi.org/10.3390/genes10050345

AMA Style

Symonová R. Integrative rDNAomics—Importance of the Oldest Repetitive Fraction of the Eukaryote Genome. Genes. 2019; 10(5):345. https://doi.org/10.3390/genes10050345

Chicago/Turabian Style

Symonová, Radka. 2019. "Integrative rDNAomics—Importance of the Oldest Repetitive Fraction of the Eukaryote Genome" Genes 10, no. 5: 345. https://doi.org/10.3390/genes10050345

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