Next Article in Journal
Impact of Chromosomal Rearrangements on the Interpretation of Lupin Karyotype Evolution
Next Article in Special Issue
Temporal Dynamics of DNA Methylation Patterns in Response to Rearing Juvenile Steelhead (Oncorhynchus mykiss) in a Hatchery versus Simulated Stream Environment
Previous Article in Journal
DNA Methylation Reprogramming during Mammalian Development
Previous Article in Special Issue
Assessing Global DNA Methylation Changes Associated with Plasticity in Seven Highly Inbred Lines of Snapdragon Plants (Antirrhinum majus)

On the Importance to Acknowledge Transposable Elements in Epigenomic Analyses

CNRS, Laboratoire de Biométrie et Biologie Evolutive, Université de Lyon, Université Lyon 1, UMR 5558, F-69622 Villeurbanne, France
Center for Research in Agricultural Genomics, CRAG (CSIC-IRTA-UAB-UB), Campus UAB, Cerdanyola del Vallès, 08193 Barcelona, Spain
CNRS, IHPE UMR 5244, University of Perpignan Via Domitia, IFREMER, University Montpellier, F-66860 Perpignan, France
Author to whom correspondence should be addressed.
Genes 2019, 10(4), 258;
Received: 4 February 2019 / Revised: 27 March 2019 / Accepted: 27 March 2019 / Published: 31 March 2019
(This article belongs to the Special Issue Epigenetics and Adaptation)
Eukaryotic genomes comprise a large proportion of repeated sequences, an important fraction of which are transposable elements (TEs). TEs are mobile elements that have a significant impact on genome evolution and on gene functioning. Although some TE insertions could provide adaptive advantages to species, transposition is a highly mutagenic event that has to be tightly controlled to ensure its viability. Genomes have evolved sophisticated mechanisms to control TE activity, the most important being epigenetic silencing. However, the epigenetic control of TEs can also affect genes located nearby that can become epigenetically regulated. It has been proposed that the combination of TE mobilization and the induced changes in the epigenetic landscape could allow a rapid phenotypic adaptation to global environmental changes. In this review, we argue the crucial need to take into account the repeated part of genomes when studying the global impact of epigenetic modifications on an organism. We emphasize more particularly why it is important to carefully consider TEs and what bioinformatic tools can be used to do so. View Full-Text
Keywords: transposable element; epigenomics; bioinformatic tools transposable element; epigenomics; bioinformatic tools
MDPI and ACS Style

Lerat, E.; Casacuberta, J.; Chaparro, C.; Vieira, C. On the Importance to Acknowledge Transposable Elements in Epigenomic Analyses. Genes 2019, 10, 258.

AMA Style

Lerat E, Casacuberta J, Chaparro C, Vieira C. On the Importance to Acknowledge Transposable Elements in Epigenomic Analyses. Genes. 2019; 10(4):258.

Chicago/Turabian Style

Lerat, Emmanuelle, Josep Casacuberta, Cristian Chaparro, and Cristina Vieira. 2019. "On the Importance to Acknowledge Transposable Elements in Epigenomic Analyses" Genes 10, no. 4: 258.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop