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Genes 2019, 10(3), 246; https://doi.org/10.3390/genes10030246

The Interaction between Sex and Hyperlipidemia on Gout Risk Is Modulated by HLA-B Polymorphic Variants in Adult Taiwanese

1
Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
2
Superintendent Office, Cathay General Hospital, Taipei 106, Taiwan
3
Department of Family Medicine, Neihu Clinic, Attending physician, Cathay General Hospital, Taipei 106, Taiwan
4
Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung 40201, Taiwan
5
Department of Internal Medicine, Cathy General Hospital, Taipei 106, Taiwan
6
School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
7
Department of Dentistry, Cathy General Hospital, Taipei 106, Taiwan
8
Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 19 February 2019 / Revised: 14 March 2019 / Accepted: 22 March 2019 / Published: 25 March 2019
(This article belongs to the Section Molecular Genetics and Genomics)
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PDF [195 KB, uploaded 25 March 2019]

Abstract

The effects of genetic variants on the interaction between hyperlipidemia and sex have not been investigated among gout patients in Taiwan. Using Taiwan Biobank and the National Health Insurance Research Database (NHIRD), we examined hyperlipidemia, sex, and their relationship with gout among Taiwanese adults with the human leukocyte antigen B (HLA-B) genetic variants. Hyperlipidemia was present in 1437 patients with gout. Sex and hyperlipidemia had significant associations on gout risk, with hyperlipidemia showing a relatively stronger effect. Gout was present in men, with an odds ratio (OR) of 1.945 (95% confidence interval (CI) 1.568–2.411) compared to women, and in hyperlipidemic (OR = 4.032; 95% CI: 3.581–4.540) compared to non-hyperlipidemic patients. The interaction of sex and hyperlipidemia was significant for rs2523608 GG (p = 0.0402) and rs4713518 AA (p = 0.0003) genotypes. After stratification, hyperlipidemia remained a risk factor in women (OR = 4.735, 95% CI: 3.375–6.643) and men (OR = 3.640, 95% CI: 2.916–4.544) with rs2523608 GG genotype. The odds ratio in hyperlipidemic women and men with rs4713518 AA genotype was 7.454 (95% CI 5.103–10.888) and 3.585 (95% CI 2.854–4.503), respectively. Our study indicates that hyperlipidemia-sex interactions exist for gout risk in Taiwanese adults with rs2523608 GG and rs4713518 AA genotypes. View Full-Text
Keywords: gout; hyperlipidemia; sex gout; hyperlipidemia; sex
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Hsu, T.-W.; Lee, P.-S.; Nfor, O.N.; Lee, C.-L.; Chen, P.-H.; Tantoh, D.M.; Lin, L.-Y.; Chou, M.-C.; Lee, Y.-C.; Liaw, Y.-P. The Interaction between Sex and Hyperlipidemia on Gout Risk Is Modulated by HLA-B Polymorphic Variants in Adult Taiwanese. Genes 2019, 10, 246.

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