Next Article in Journal
Knockdown of Cytochrome P450 Genes Gh_D07G1197 and Gh_A13G2057 on Chromosomes D07 and A13 Reveals Their Putative Role in Enhancing Drought and Salt Stress Tolerance in Gossypium hirsutum
Next Article in Special Issue
The Elaboration of miRNA Regulation and Gene Regulatory Networks in Plant–Microbe Interactions
Previous Article in Journal
Differential Alternative Splicing Genes in Response to Boron Deficiency in Brassica napus
Previous Article in Special Issue
Population Genetic and Functional Analysis of a cis-Regulatory Polymorphism in the Drosophila melanogaster Metallothionein A gene
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Genes 2019, 10(3), 225; https://doi.org/10.3390/genes10030225

Gene Expression Networks Across Multiple Tissues Are Associated with Rates of Molecular Evolution in Wild House Mice

1
Department of Integrative Biology and Museum of Vertebrate Zoology, University of California, Berkeley, CA 94720, USA
2
Department of Biology, Monmouth University, West Long Branch, NJ 07764, USA
3
Max-Planck-Institute for Evolutionary Biology, Plön 24306, Germany
*
Authors to whom correspondence should be addressed.
Received: 28 January 2018 / Revised: 10 March 2019 / Accepted: 11 March 2019 / Published: 18 March 2019
(This article belongs to the Special Issue Evolutionary Genetics of Gene Expression)
  |  
PDF [1243 KB, uploaded 18 March 2019]
  |  

Abstract

Interactions between genes can influence how selection acts on sequence variation. In gene regulatory networks, genes that affect the expression of many other genes may be under stronger evolutionary constraint than genes whose expression affects fewer partners. While this has been studied for individual tissue types, we know less about the effects of regulatory networks on gene evolution across different tissue types. We use RNA-sequencing and genomic data collected from Mus musculus domesticus to construct and compare gene co-expression networks for 10 tissue types. We identify tissue-specific expression and local regulatory variation, and we associate these components of gene expression variation with sequence polymorphism and divergence. We found that genes with higher connectivity across tissues and genes associated with a greater number of cross-tissue modules showed significantly lower genetic diversity and lower rates of protein evolution. Consistent with this pattern, “hub” genes across multiple tissues also showed evidence of greater evolutionary constraint. Using allele-specific expression, we found that genes with cis-regulatory variation had lower average connectivity and higher levels of tissue specificity. Taken together, these results are consistent with strong purifying selection acting on genes with high connectivity within and across tissues. View Full-Text
Keywords: co-expression; gene regulation; house mice co-expression; gene regulation; house mice
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Mack, K.L.; Phifer-Rixey, M.; Harr, B.; Nachman, M.W. Gene Expression Networks Across Multiple Tissues Are Associated with Rates of Molecular Evolution in Wild House Mice. Genes 2019, 10, 225.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top