Next Article in Journal
Pharmacogenomic and Pharmacotranscriptomic Profiling of Childhood Acute Lymphoblastic Leukemia: Paving the Way to Personalized Treatment
Previous Article in Journal
Genome Sequencing Illustrates the Genetic Basis of the Pharmacological Properties of Gloeostereum incarnatum
Previous Article in Special Issue
Gene Variations in Cis-Acting Elements between the Taiwan and Prototype Strains of Porcine Epidemic Diarrhea Virus Alter Viral Gene Expression
Open AccessReview

RNA Viruses as Tools in Gene Therapy and Vaccine Development

PanTherapeutics, Rte de Lavaux 49, CH1095 Lutry, Switzerland
Genes 2019, 10(3), 189; https://doi.org/10.3390/genes10030189
Received: 31 January 2019 / Revised: 19 February 2019 / Accepted: 21 February 2019 / Published: 1 March 2019
(This article belongs to the Special Issue Viral Genes and the Host: Evolution in Action)
RNA viruses have been subjected to substantial engineering efforts to support gene therapy applications and vaccine development. Typically, retroviruses, lentiviruses, alphaviruses, flaviviruses rhabdoviruses, measles viruses, Newcastle disease viruses, and picornaviruses have been employed as expression vectors for treatment of various diseases including different types of cancers, hemophilia, and infectious diseases. Moreover, vaccination with viral vectors has evaluated immunogenicity against infectious agents and protection against challenges with pathogenic organisms. Several preclinical studies in animal models have confirmed both immune responses and protection against lethal challenges. Similarly, administration of RNA viral vectors in animals implanted with tumor xenografts resulted in tumor regression and prolonged survival, and in some cases complete tumor clearance. Based on preclinical results, clinical trials have been conducted to establish the safety of RNA virus delivery. Moreover, stem cell-based lentiviral therapy provided life-long production of factor VIII potentially generating a cure for hemophilia A. Several clinical trials on cancer patients have generated anti-tumor activity, prolonged survival, and even progression-free survival. View Full-Text
Keywords: RNA viruses; gene therapy; vaccine; animal models; clinical trials; immunogenicity; protection; cancer therapy; prolonged survival RNA viruses; gene therapy; vaccine; animal models; clinical trials; immunogenicity; protection; cancer therapy; prolonged survival
MDPI and ACS Style

Lundstrom, K. RNA Viruses as Tools in Gene Therapy and Vaccine Development. Genes 2019, 10, 189.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop