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A “NOTCH” Deeper into the Epithelial-To-Mesenchymal Transition (EMT) Program in Breast Cancer

Indian Institute of Management Ahmedabad (IIMA), Gujarat 380015, India
Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida 201306, India
Department of Life Science, School of Basic Science & Research (SBSR), Sharda University, Greater Noida 201306, India
National Centre of Experimental Mineralogy & Petrology (NCEMP), University of Allahabad, Prayagraj 2l1002, India
Author to whom correspondence should be addressed.
Genes 2019, 10(12), 961;
Received: 29 August 2019 / Revised: 14 November 2019 / Accepted: 18 November 2019 / Published: 22 November 2019
(This article belongs to the Special Issue The Role of Genotoxicity in Infertility and Cancer Development)
Notch signaling is a primitive signaling pathway having various roles in the normal origin and development of each multicellular organisms. Therefore, any aberration in the pathway will inevitably lead to deadly outcomes such as cancer. It has now been more than two decades since Notch was acknowledged as an oncogene in mouse mammary tumor virus-infected mice. Since that discovery, activated Notch signaling and consequent up-regulation of tumor-promoting Notch target genes have been observed in human breast cancer. Moreover, consistent over-expression of Notch ligands and receptors has been shown to correlate with poor prognosis in human breast cancer. Notch regulates a number of key processes during breast carcinogenesis, of which, one key phenomenon is epithelial–mesenchymal transition (EMT). EMT is a key process for large-scale cell movement during morphogenesis at the time of embryonic development. Cancer cells aided by transcription factors usurp this developmental program to execute the multi-step process of tumorigenesis and metastasis. In this review, we recapitulate recent progress in breast cancer research that has provided new perceptions into the molecular mechanisms behind Notch-mediated EMT regulation during breast tumorigenesis. View Full-Text
Keywords: Notch; EMT; breast cancer; metastasis; invasion; signaling pathway; hypoxia; cytokine; PI3K/Akt Notch; EMT; breast cancer; metastasis; invasion; signaling pathway; hypoxia; cytokine; PI3K/Akt
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Kar, R.; Jha, N.K.; Jha, S.K.; Sharma, A.; Dholpuria, S.; Asthana, N.; Chaurasiya, K.; Singh, V.K.; Burgee, S.; Nand, P. A “NOTCH” Deeper into the Epithelial-To-Mesenchymal Transition (EMT) Program in Breast Cancer. Genes 2019, 10, 961.

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