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Genome-Wide Analysis of Known and Potential Tetraspanins in Entamoeba histolytica

Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan
Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Authors to whom correspondence should be addressed.
Genes 2019, 10(11), 885;
Received: 29 August 2019 / Revised: 25 October 2019 / Accepted: 31 October 2019 / Published: 3 November 2019
(This article belongs to the Section Microbial Genetics and Genomics)
Tetraspanins are membrane proteins involved in intra- and/or intercellular signaling, and membrane protein complex formation. In some organisms, their role is associated with virulence and pathogenesis. Here, we investigate known and potential tetraspanins in the human intestinal protozoan parasite Entamoeba histolytica. We conducted sequence similarity searches against the proteome data of E. histolytica and newly identified nine uncharacterized proteins as potential tetraspanins in E. histolytica. We found three subgroups within known and potential tetraspanins, as well as subgroup-associated features in both their amino acid and nucleotide sequences. We also examined the subcellular localization of a few representative tetraspanins that might be potentially related to pathogenicity. The results in this study could be useful resources for further understanding and downstream analyses of tetraspanins in Entamoeba.
Keywords: tetraspanin; Entamoeba; membrane protein; subcellular localization; intron tetraspanin; Entamoeba; membrane protein; subcellular localization; intron
MDPI and ACS Style

Tomii, K.; Santos, H.J.; Nozaki, T. Genome-Wide Analysis of Known and Potential Tetraspanins in Entamoeba histolytica. Genes 2019, 10, 885.

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