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Cholesteryl Ester Transfer Protein Genetic Variants Associated with Risk for Type 2 Diabetes and Diabetic Kidney Disease in Taiwanese Population

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School of Chinese Medicine, China Medical University, Taichung 404, Taiwan
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Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan
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Center for Translational Medicine, China Medical University Hospital, Taichung 404, Taiwan
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Graduate Institute of Biomedical Science, China Medical University, Taichung 404, Taiwan
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Department of Ophthalmology, China Medical University Hospital, Taichung 404, Taiwan
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Department of Public Health, China Medical University, Taichung 404, Taiwan
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Department of Anatomical Pathology, Taipei Institute of Pathology, Taipei 103, Taiwan
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Center for Personalized Medicine, China Medical University Hospital, Taichung 404, Taiwan
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Graduate Institute of Integrated Medicine, China Medical University, Taichung 404, Taiwan
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Department of Pediatric Internal Medicine, Children’s Hospital of China Medical University, Taichung 404, Taiwan
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Department of Medical Genetics, China Medical University Hospital, Taichung 404, Taiwan
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Authors to whom correspondence should be addressed.
Genes 2019, 10(10), 782; https://doi.org/10.3390/genes10100782
Received: 13 July 2019 / Revised: 24 September 2019 / Accepted: 2 October 2019 / Published: 8 October 2019
(This article belongs to the Section Human Genomics and Genetic Diseases)
Cholesteryl ester transfer protein (CETP) plays an important role in lipid metabolism. Low levels of high-density lipoprotein cholesterol (HDL-C) increase the risk of type 2 diabetes (T2D). This study investigated CETP gene variants to assess the risk of T2D and specific complications of diabetic kidney disease (DKD) and diabetic retinopathy. Towards this, a total of 3023 Taiwanese individuals (1383 without T2D, 1640 with T2D) were enrolled in this study. T2D mice (+Leprdb/+Leprdb, db/db) were used to determine CETP expression in tissues. The A-alleles of rs3764261, rs4783961, and rs1800775 variants were found to be independently associated with 2.86, 1.71, and 0.91 mg/dL increase in HDL-C per allele, respectively. In addition, the A-allele of rs4783961 was significantly associated with a reduced T2D risk (odds ratio (OR), 0.82; 95% confidence interval (CI), 0.71‒0.96)), and the A-allele of rs1800775 was significantly related to a lowered DKD risk (OR, 0.78; 95% CI, 0.64‒0.96). CETP expression was significantly decreased in the T2D mice kidney compared to that in the control mice (T2D mice, 0.16 0.01 vs. control mice, 0.21 0.02; p = 0.02). These collective findings indicate that CETP variants in the promoter region may affect HDL-C levels. Taiwanese individuals possessing an allele associated with higher HDL-C levels had a lower risk of T2D and DKD.
Keywords: CETP; HDL-C; type 2 diabetes; diabetic kidney disease; diabetic retinopathy CETP; HDL-C; type 2 diabetes; diabetic kidney disease; diabetic retinopathy
MDPI and ACS Style

Huang, Y.-C.; Chen, S.-Y.; Liu, S.-P.; Lin, J.-M.; Lin, H.-J.; Lei, Y.-J.; Chung, Y.-C.; Chen, Y.-C.; Wang, Y.-H.; Liao, W.-L.; Tsai, F.-J. Cholesteryl Ester Transfer Protein Genetic Variants Associated with Risk for Type 2 Diabetes and Diabetic Kidney Disease in Taiwanese Population. Genes 2019, 10, 782.

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