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Open AccessArticle

A Portal to Visualize Transcriptome Profiles in Mouse Models of Neurological Disorders

1
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
2
Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX 77030, USA
3
Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
4
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
5
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally.
Genes 2019, 10(10), 759; https://doi.org/10.3390/genes10100759
Received: 28 June 2019 / Revised: 21 September 2019 / Accepted: 23 September 2019 / Published: 26 September 2019
Target nomination for drug development has been a major challenge in the path to finding a cure for several neurological disorders. Comprehensive transcriptome profiles have revealed brain gene expression changes associated with many neurological disorders, and the functional validation of these changes is a critical next step. Model organisms are a proven approach for the elucidation of disease mechanisms, including screening of gene candidates as therapeutic targets. Frequently, multiple models exist for a given disease, creating a challenge to select the optimal model for validation and functional follow-up. To help in nominating the best mouse models for studying neurological diseases, we developed a web portal to visualize mouse transcriptomic data related to neurological disorders. Users can examine gene expression changes across mouse model studies to help select the optimal mouse model for further investigation. The portal provides access to mouse studies related to Alzheimer’s diseases (AD), Parkinson’s disease (PD), Huntington’s disease (HD), Amyotrophic Lateral Sclerosis (ALS), Spinocerebellar ataxia (SCA), and models related to aging. View Full-Text
Keywords: neurodegeneration; neurological disorders; mouse models; transcriptomics neurodegeneration; neurological disorders; mouse models; transcriptomics
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Al-Ouran, R.; Wan, Y.-W.; Mangleburg, C.G.; Lee, T.V.; Allison, K.; Shulman, J.M.; Liu, Z. A Portal to Visualize Transcriptome Profiles in Mouse Models of Neurological Disorders. Genes 2019, 10, 759.

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