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Open AccessArticle

Comparative Analysis of Fecal Microbiota Composition Between Rheumatoid Arthritis and Osteoarthritis Patients

Department of Internal Medicine, Kosin University College of Medicine, Busan 49104, Korea
Department of Integrated Biological Science, Pusan National University, Busan 46241, Korea
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Genes 2019, 10(10), 748;
Received: 31 August 2019 / Revised: 15 September 2019 / Accepted: 24 September 2019 / Published: 25 September 2019
(This article belongs to the Section Human Genomics and Genetic Diseases)
The aim of this study was to investigate differences between the gut microbiota composition in patients with rheumatoid arthritis (RA) and those with osteoarthritis (OA). Stool samples from nine RA patients and nine OA patients were collected, and DNA was extracted. The gut microbiome was assessed using 16S rRNA gene amplicon sequencing. The structures and differences in the gut microbiome between RA and OA were analyzed. The analysis of diversity revealed no differences in the complexity of samples. The RA group had a lower Bacteroidetes: Firmicutes ratio than did the OA group. Lactobacilli and Prevotella, particularly Prevotella copri, were more abundant in the RA than in the OA group, although these differences were not statistically significant. The relative abundance of Bacteroides and Bifidobacterium was lower in the RA group. At the species level, the abundance of certain bacterial species was significantly lower in the RA group, such as Fusicatenibacter saccharivorans, Dialister invisus, Clostridium leptum, Ruthenibacterium lactatiformans, Anaerotruncus colihominis, Bacteroides faecichinchillae, Harryflintia acetispora, Bacteroides acidifaciens, and Christensenella minuta. The microbial properties of the gut differed between RA and OA patients, and the RA dysbiosis revealed results similar to those of other autoimmune diseases, suggesting that a specific gut microbiota pattern is related to autoimmunity. View Full-Text
Keywords: rheumatoid arthritis; osteoarthritis; gut microbiota rheumatoid arthritis; osteoarthritis; gut microbiota
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MDPI and ACS Style

Lee, J.-Y.; Mannaa, M.; Kim, Y.; Kim, J.; Kim, G.-T.; Seo, Y.-S. Comparative Analysis of Fecal Microbiota Composition Between Rheumatoid Arthritis and Osteoarthritis Patients. Genes 2019, 10, 748.

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