Comparative Analysis of Fecal Microbiota Composition Between Rheumatoid Arthritis and Osteoarthritis Patients
Abstract
:1. Introduction
2. Patients and Methods
2.1. Patients
2.2. Sampling and DNA Extraction
2.3. Sequencing, Bioinformatic Analysis, and Assignment of the Microbiota Composition
2.4. Statistical Analysis
3. Results
3.1. Characteristics of the Study Participants and the Obtained Reads
3.2. Diversity Analysis of the Fecal Microbial Composition Between RA and OA Patients
3.3. Relative Abundances of Bacterial Taxa at Different Taxonomic Levels Between RA and OA Patients
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Rheumatoid Arthritis (n = 9) | Osteoarthritis (n = 9) | p Value | |
---|---|---|---|
Age | 55.00 ± 5.21 | 59.78 ± 8.18 | 0.182 |
Weight | 61.47 ± 7.36 | 58.59 ± 7.77 | 0.458 |
BMI | 24.66 ± 3.21 | 24.48 ± 2.86 | 0.907 |
ESR (mm/h) | 32.33 ± 12.82 | 18.11 ± 8.17 | 0.018 |
hsCRP (mg/dL) | 0.46 ± 0.56 | 0.13 ± 0.25 | 0.035 |
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Lee, J.-Y.; Mannaa, M.; Kim, Y.; Kim, J.; Kim, G.-T.; Seo, Y.-S. Comparative Analysis of Fecal Microbiota Composition Between Rheumatoid Arthritis and Osteoarthritis Patients. Genes 2019, 10, 748. https://doi.org/10.3390/genes10100748
Lee J-Y, Mannaa M, Kim Y, Kim J, Kim G-T, Seo Y-S. Comparative Analysis of Fecal Microbiota Composition Between Rheumatoid Arthritis and Osteoarthritis Patients. Genes. 2019; 10(10):748. https://doi.org/10.3390/genes10100748
Chicago/Turabian StyleLee, Jin-Young, Mohamed Mannaa, Yunkyung Kim, Jehun Kim, Geun-Tae Kim, and Young-Su Seo. 2019. "Comparative Analysis of Fecal Microbiota Composition Between Rheumatoid Arthritis and Osteoarthritis Patients" Genes 10, no. 10: 748. https://doi.org/10.3390/genes10100748