Next Article in Journal
m6A mRNA Destiny: Chained to the rhYTHm by the YTH-Containing Proteins
Next Article in Special Issue
A Review of Epigenetics of PTSD in Comorbid Psychiatric Conditions
Previous Article in Journal
Genome-Wide Identification and Transcriptional Expression of the PAL Gene Family in Common Walnut (Juglans Regia L.)
Previous Article in Special Issue
Genomic Enhancers in Brain Health and Disease
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessReview
Genes 2019, 10(1), 47; https://doi.org/10.3390/genes10010047

Animal Models and Their Contribution to Our Understanding of the Relationship Between Environments, Epigenetic Modifications, and Behavior

Department of Psychological and Brain Sciences, University of Delaware, 108 Wolf Hall, Newark, DE 19716, USA
*
Author to whom correspondence should be addressed.
Received: 22 November 2018 / Revised: 29 December 2018 / Accepted: 10 January 2019 / Published: 15 January 2019
(This article belongs to the Special Issue Epigenetics, Environment, and Brain Disorders)
Full-Text   |   PDF [1018 KB, uploaded 22 January 2019]   |  

Abstract

The use of non-human animals in research is a longstanding practice to help us understand and improve human biology and health. Animal models allow researchers, for example, to carefully manipulate environmental factors in order to understand how they contribute to development, behavior, and health. In the field of behavioral epigenetics such approaches have contributed novel findings of how the environment physically interacts with our genes, leading to changes in behavior and health. This review highlights some of this research, focused on prenatal immune challenges, environmental toxicants, diet, and early-life stress. In conjunction, we also discuss why animal models were integral to these discoveries and the translational relevance of these discoveries. View Full-Text
Keywords: animal models; environments; epigenetics; behavior; disease animal models; environments; epigenetics; behavior; disease
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Phillips, N.L.H.; Roth, T.L. Animal Models and Their Contribution to Our Understanding of the Relationship Between Environments, Epigenetic Modifications, and Behavior. Genes 2019, 10, 47.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top