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Jumonji C Demethylases in Cellular Senescence

Department of Cellular & Molecular Physiology, Penn Stage College of Medicine, Hershey, PA 17033, USA
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Genes 2019, 10(1), 33; https://doi.org/10.3390/genes10010033
Received: 13 November 2018 / Revised: 20 December 2018 / Accepted: 3 January 2019 / Published: 9 January 2019
(This article belongs to the Section Molecular Genetics and Genomics)
Senescence is a stable cell cycle arrest that is either tumor suppressive or tumor promoting depending on context. Epigenetic changes such as histone methylation are known to affect both the induction and suppression of senescence by altering expression of genes that regulate the cell cycle and the senescence-associated secretory phenotype. A conserved group of proteins containing a Jumonji C (JmjC) domain alter chromatin state, and therefore gene expression, by demethylating histones. Here, we will discuss what is currently known about JmjC demethylases in the induction of senescence, and how these enzymes suppress senescence to contribute to tumorigenesis. View Full-Text
Keywords: epigenetics; cell cycle; metabolism; histones; senescence-associated secretory phenotype; senescence-associated heterochromatin foci; p53; retinoblastoma protein epigenetics; cell cycle; metabolism; histones; senescence-associated secretory phenotype; senescence-associated heterochromatin foci; p53; retinoblastoma protein
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Leon, K.E.; Aird, K.M. Jumonji C Demethylases in Cellular Senescence. Genes 2019, 10, 33.

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