Jumonji C Demethylases in Cellular Senescence
AbstractSenescence is a stable cell cycle arrest that is either tumor suppressive or tumor promoting depending on context. Epigenetic changes such as histone methylation are known to affect both the induction and suppression of senescence by altering expression of genes that regulate the cell cycle and the senescence-associated secretory phenotype. A conserved group of proteins containing a Jumonji C (JmjC) domain alter chromatin state, and therefore gene expression, by demethylating histones. Here, we will discuss what is currently known about JmjC demethylases in the induction of senescence, and how these enzymes suppress senescence to contribute to tumorigenesis. View Full-Text
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Leon, K.E.; Aird, K.M. Jumonji C Demethylases in Cellular Senescence. Genes 2019, 10, 33.
Leon KE, Aird KM. Jumonji C Demethylases in Cellular Senescence. Genes. 2019; 10(1):33.Chicago/Turabian Style
Leon, Kelly E.; Aird, Katherine M. 2019. "Jumonji C Demethylases in Cellular Senescence." Genes 10, no. 1: 33.
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