ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. RT–PCR of mRNA
2.3. Statistical Analysis
3. Results
3.1. Detection of ZMPSTE24, Lamin A/C and Progerin mRNA in Human Blood Samples
3.2. Characteristics of Study Cohort
3.3. Lamin A/C and ZMPSTE24 mRNA Correlate with Progerin mRNA
3.4. CRP Correlates with Expression of Lamin A/C and ZMPSTE24 mRNA
4. Discussion
Limitations
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
BMI | Body mass index |
CVS | Cardiovascular system |
DCMP | Dilative cardiomyopathy |
HGPS | Hutchinson–-Gilford progeria syndrome |
Hs-CRP | High-sensitive C-reactive protein |
HCMP | Hypertrophic cardiomyopathy |
ICMP | Ischemic cardiomyopathy |
NYHA | New York Heart Association |
PCR | Polymerase chain reaction |
Appendix A
DCMP | ICMP | HCMP | Others | Total |
---|---|---|---|---|
58 (53) | 31 (28) | 12 (11) | 9 (8) | 110 |
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Characteristic | Total Population N = 110 | |
---|---|---|
Age, years | 56 ± 15 | |
Female sex, n (%) | 32 (29) | |
Body mass index, kg/m2 | 26.6 ± 4.8 | |
NYHA class, n (%) | N = 108 | 2.0 ± 0.7 |
I | 29 (26) | |
II | 55 (50) | |
III | 24 (22) | |
IV | 0 (0) | |
Medical history, n (%) | ||
Smoking, n (%) | N = 108 | 49 |
Diabetes, n (%) | 19 (17) | |
Atrial fibrillation, n (%) | 42 (38) | |
LVEF, n (%) | 38.2 ± 14.9 | |
ACE-inhibitor, n (%) | 55 (50) | |
ARB, n (%) | 33 (30) | |
Beta blocker | 90 (81) | |
Clinical features | ||
NT-proBNP, ng/L | N = 108 | 2094 ± 4421 |
Troponin T, ng/L | N = 109 | 28 ± 53 |
Serum creatinine, mg/dl | 1.2 ± 0.46 | |
GFR, mL/min | 54 ± 10 | |
Urea, mg/dl | 50 ± 37 | |
HbA1c,% | N = 110 | 5.9 ± 1.0 |
Triglycerides, mg/dl | 135 ± 68 | |
Total cholesterol, mg/dl | 172 ± 44 | |
LDL, mg/dl | N = 109 | 107 ± 37 |
HDL, mg/dl | N = 109 | 52 ± 19 |
Hs-CRP, mg/dl | N = 110 | 0.64 ± 1.07 |
GGT, U/I | 86 ± 146 | |
GOT, U/I | 29.2 ± 12.4 | |
Potassium | 4.2 ± 0.5 | |
Sodium | 138 ± 13 | |
Leucocyte count, G/L | 7.7 ± 2.2 | |
Thrombocytes, G/I | 217 ± 71 | |
Hemoglobin, g/L | 140 ± 15 |
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Messner, M.; Ghadge, S.K.; Maurer, T.; Graber, M.; Staggl, S.; Christine Maier, S.; Pölzl, G.; Zaruba, M.-M. ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA. Cells 2020, 9, 1981. https://doi.org/10.3390/cells9091981
Messner M, Ghadge SK, Maurer T, Graber M, Staggl S, Christine Maier S, Pölzl G, Zaruba M-M. ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA. Cells. 2020; 9(9):1981. https://doi.org/10.3390/cells9091981
Chicago/Turabian StyleMessner, Moritz, Santhosh Kumar Ghadge, Thomas Maurer, Michael Graber, Simon Staggl, Sarah Christine Maier, Gerhard Pölzl, and Marc-Michael Zaruba. 2020. "ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA" Cells 9, no. 9: 1981. https://doi.org/10.3390/cells9091981