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Robustness during Aging—Molecular Biological and Physiological Aspects

1
RNA Bioinformatics/High Throughput Analysis, Faculty of Mathematics and Computer Science, Friedrich Schiller University Jena, 07743 Jena, Germany
2
Matthias Schleiden Institute, Bioinformatics, Friedrich Schiller University Jena, 07743 Jena, Germany
3
Institute of Zoology and Evolutionary Research with Phyletic Museum, Friedrich Schiller University Jena, 07743 Jena, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2020, 9(8), 1862; https://doi.org/10.3390/cells9081862
Received: 18 June 2020 / Revised: 27 July 2020 / Accepted: 5 August 2020 / Published: 8 August 2020
(This article belongs to the Special Issue Aging and Regeneration)
Understanding the process of aging is still an important challenge to enable healthy aging and to prevent age-related diseases. Most studies in age research investigate the decline in organ functionality and gene activity with age. The focus on decline can even be considered a paradigm in that field. However, there are certain aspects that remain surprisingly stable and keep the organism robust. Here, we present and discuss various properties of robust behavior during human and animal aging, including physiological and molecular biological features, such as the hematocrit, body temperature, immunity against infectious diseases and others. We examine, in the context of robustness, the different theories of how aging occurs. We regard the role of aging in the light of evolution. View Full-Text
Keywords: age-related diseases; failure accumulation; healthy aging; immunosenescence; robustness; theories of aging age-related diseases; failure accumulation; healthy aging; immunosenescence; robustness; theories of aging
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MDPI and ACS Style

Barth, E.; Sieber, P.; Stark, H.; Schuster, S. Robustness during Aging—Molecular Biological and Physiological Aspects. Cells 2020, 9, 1862. https://doi.org/10.3390/cells9081862

AMA Style

Barth E, Sieber P, Stark H, Schuster S. Robustness during Aging—Molecular Biological and Physiological Aspects. Cells. 2020; 9(8):1862. https://doi.org/10.3390/cells9081862

Chicago/Turabian Style

Barth, Emanuel, Patricia Sieber, Heiko Stark, and Stefan Schuster. 2020. "Robustness during Aging—Molecular Biological and Physiological Aspects" Cells 9, no. 8: 1862. https://doi.org/10.3390/cells9081862

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