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10.3390/cells9061457
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Article

Ablation of Vitamin D Signaling Compromises Cerebrovascular Adaptation to Carotid Artery Occlusion in Mice

by
Éva Pál
1,*,
László Hricisák
1,
Ágnes Lékai
1,
Dorina Nagy
1,
Ágnes Fülöp
1,
Reinhold G. Erben
2,
Szabolcs Várbíró
3,
Péter Sándor
1 and
Zoltán Benyó
1,*
1
Institute of Translational Medicine, Semmelweis University, 1094 Budapest, Hungary
2
Department of Biomedical Sciences, University of Veterinary Medicine Vienna, 1210 Vienna, Austria
3
Department of Obstetrics and Gynecology, Semmelweis University, 1082 Budapest, Hungary
*
Authors to whom correspondence should be addressed.
Cells 2020, 9(6), 1457; https://doi.org/10.3390/cells9061457
Submission received: 26 May 2020 / Revised: 9 June 2020 / Accepted: 10 June 2020 / Published: 12 June 2020
(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Cerebral Ischemia)
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Abstract

Vitamin D insufficiency has been associated with increased incidence and severity of cerebrovascular disorders. We analyzed the impact of impaired vitamin D signaling on the anatomical and functional aspects of cerebrovascular adaptation to unilateral carotid artery occlusion (CAO), a common consequence of atherosclerosis and cause of ischemic stroke. Cerebrocortical blood flow (CoBF) showed a significantly increased drop and delayed recovery after CAO in mice carrying a functionally inactive vitamin D receptor (VDR) with the most sustained perfusion deficit in the temporal cortex. To identify the cause(s) for this altered adaptation, the extent of compensatory blood flow increase in the contralateral carotid artery and the morphology of pial collaterals between the anterior and middle cerebral arteries were determined. Whereas VDR deficiency had no significant influence on the contralateral carotid arterial blood flow increase, it was associated with decreased number and increased tortuosity of pial anastomoses resulting in unfavorable changes of the intracranial collateral circulation. These results indicate that VDR deficiency compromises the cerebrovascular adaptation to CAO with the most sustained consequences in the temporal cortex. The dysregulation can be attributed to the altered development and function of pial collateral circulation whereas extracranial vessels may not be impaired.
Keywords: carotid artery occlusion; pial collateral circulation; vitamin D receptor deficiency; cerebrovascular dysregulation; atherosclerosis carotid artery occlusion; pial collateral circulation; vitamin D receptor deficiency; cerebrovascular dysregulation; atherosclerosis

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MDPI and ACS Style

Pál, É.; Hricisák, L.; Lékai, Á.; Nagy, D.; Fülöp, Á.; Erben, R.G.; Várbíró, S.; Sándor, P.; Benyó, Z. Ablation of Vitamin D Signaling Compromises Cerebrovascular Adaptation to Carotid Artery Occlusion in Mice. Cells 2020, 9, 1457. https://doi.org/10.3390/cells9061457

AMA Style

Pál É, Hricisák L, Lékai Á, Nagy D, Fülöp Á, Erben RG, Várbíró S, Sándor P, Benyó Z. Ablation of Vitamin D Signaling Compromises Cerebrovascular Adaptation to Carotid Artery Occlusion in Mice. Cells. 2020; 9(6):1457. https://doi.org/10.3390/cells9061457

Chicago/Turabian Style

Pál, Éva, László Hricisák, Ágnes Lékai, Dorina Nagy, Ágnes Fülöp, Reinhold G. Erben, Szabolcs Várbíró, Péter Sándor, and Zoltán Benyó. 2020. "Ablation of Vitamin D Signaling Compromises Cerebrovascular Adaptation to Carotid Artery Occlusion in Mice" Cells 9, no. 6: 1457. https://doi.org/10.3390/cells9061457

APA Style

Pál, É., Hricisák, L., Lékai, Á., Nagy, D., Fülöp, Á., Erben, R. G., Várbíró, S., Sándor, P., & Benyó, Z. (2020). Ablation of Vitamin D Signaling Compromises Cerebrovascular Adaptation to Carotid Artery Occlusion in Mice. Cells, 9(6), 1457. https://doi.org/10.3390/cells9061457

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